HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
N,N- diallyl- tyrosyl- alpha- aminoisobutyric acid-phenylalanyl-leucine
Also Known As:
ICI 174864; ICI-174864; N,N-diallyl-Tyr-Aib-Phe-Leu; L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)-
Networked:
12
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Enkephalins: 1042
Leucine Enkephalin: 304
N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine: 12
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Enkephalins: 1042
Leucine Enkephalin: 304
N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine: 12
Related Diseases
1.
Paralysis (Palsy)
03/01/1988 - "
Barrel rolling and hindlimb paralysis are also produced by dynorphin A-related peptides; however, rats failed to demonstrate tolerance or cross-tolerance to the hindlimb paralytic actions of ICI 174864 or dynorphin A (1-13) after 7 days of continuous spinal intrathecal infusion of either of these compounds.
"
11/01/1988 - "
The similar pattern of cardiovascular and antinociceptive responses to other peptides (dynorphin A, somatostatin, and ICI 174864), which also caused hindlimb paralysis, suggests that the former responses may actually reflect the nonselective consequences of a peptide-induced disruption of spinal cord function, rather than specific shared pharmacological effects.
"
09/01/1988 - "
In rats, the spinal subarachnoid injection of the kappa opioid agonist Dynorphin A (Dyn A)(1-13) and the delta opioid receptor antagonist ICI 174864 produced dose-related flaccid paralysis of hindlimbs and tail that were influenced appreciably by injection procedures.
"
2.
Hypotension (Low Blood Pressure)
12/01/1984 - "
Additionally, pretreatment with dynorphin 1-13 prevented the subsequent reversal of endotoxemic hypotension by ICI 174864.
"
12/01/1984 - "
The putative delta opioid receptor antagonist ICI 174864 (3 mg/kg, i.v.) significantly reversed endotoxic shock hypotension at a dose which lacked significant pressor actions in normotensive, non-endotoxemic rats.
"
12/01/1984 - "
ICI 174864, a putative delta opioid antagonist, reverses endotoxemic hypotension: pretreatment with dynorphin 1-13, A kappa agonist, blocks this action.
"
12/01/1987 - "
Intra-NTS microinjection of 280 fmol of beta-endorphin caused hypotension and bradycardia, and these effects were similarly inhibited by ICI 174864 in SHR and by beta-funaltrexamine in Sprague-Dawley rats.
"
01/01/1999 - "
In separate experiments, the subtype-specific opioid antagonists ICI-174864 (delta-antagonist), norbinaltorphimine (nor-BNI; kappa-antagonist), and H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP; mu-antagonist) were each administered intrathecally to determine the minimum dose that would attenuate hypotension during severe hemorrhage.
"
3.
Stupor
10/27/1987 - "
The effect of neurotensin, TRH and the delta-opioid receptor antagonist ICI 174864 on alcohol-induced narcosis in rats.
"
10/27/1987 - "
The effects of microinjections of thyrotropin-releasing hormone (TRH), neurotensin and ICI 174864 into the nucleus accumbens, nucleus caudatus, septum and mesencephalic periaqueductal grey were studied on ethanol-induced narcosis in the rat.
"
4.
Urinary Incontinence
03/01/1988 - "
Whereas hindlimb responses to low doses of ICI 174864 (1.6-6.2 nmol intrathecally) were usually transient, higher doses (6.2-25 nmol intrathecally) produced persistent hindlimb motor dysfunction, altered nociception, priapism, hindlimb edema, bladder infarction and atony and urinary incontinence.
"
5.
Status Epilepticus (Complex Partial Status Epilepticus)
03/01/1999 - "
Injection into the hilus of dynorphin-A(1-13) after the end of perforant path stimulation, stopped established status epilepticus, while administration of naloxone, naltrindole and ICI-174864 were ineffective.
"
Related Drugs and Biologics
1.
delta Opioid Receptors (delta Opioid Receptor)
2.
Dynorphins (Dynorphin)
3.
Peptides (Polypeptides)
4.
Narcotic Antagonists (Opioid Antagonists)
5.
Naloxone (Narcan)
6.
Opioid Analgesics (Opioids)
7.
kappa Opioid Receptors (kappa Opioid Receptor)
8.
Thyrotropin-Releasing Hormone (Protirelin)
9.
Somatostatin (Somatotropin Release-Inhibiting Factor)
10.
Neurotensin