genistin

04/01/2013 - "sessilifolia extract and its fraction 18-22 containing genistin and isoprunetin, were able to induce anti-cancer effects supporting the hypothesis of a pro-apoptotic intrinsic content of this natural medicinal plant."
02/01/2006 - "Mice treated with genistin and SPC had reduced final tumor weights by 56% (P < 0.05) and 52% (P < 0.05), respectively, associated with induction of tumor cell apoptosis and inhibition of tumor angiogenesis in vivo. "
04/01/2020 - "Genistin has been described to have several beneficial health impacts, such as decreasing the risk of osteoporosis and post-menopausal symptoms, as well as anti-cancer, anti-oxidative, cardioprotective, anti-apoptotic, neuroprotective, hepatoprotective, and anti-microbial activities. "
12/15/2020 - "Genistin (GS) is one of isoflavones that can exert diverse pharmacological effects including that of anti-proliferation, anti-tumor angiogenesis, induce cell cycle arrest and apoptosis. "
10/01/2004 - "These effects might offer a promising novel method in designing functional foods for cancer prevention by combining genistin- and phloridzin-containing foods."

08/13/2023 - "In addition, the obtained results suggest that genistin could pave the way for new drug discovery to manage breast cancer and has potential in the development of nutraceuticals."
01/01/2023 - "Isolated compound (genistin) was evaluated for in vitro antiproliferative activity against breast cancer cell line (MCF-7 and MDA-MB-231). "
12/15/2020 - "Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway."
09/01/2012 - "Formation of breast carcinoma in DMBA-induced rats and abnormal changes were ameliorated in the rats treated with genistin/selenium or genistin alone. "
09/01/2012 - "Prevention of rat breast cancer by genistin and selenium."

08/01/2008 - "Further studies are needed to establish the optimal dose of genistin and ipriflavone, individually or in combination, for the prevention of mammary tumorigenesis."
08/01/2000 - "Possible chemopreventive effects of genistin or daidzin on rat prostate carcinogenesis were therefore investigated. "
08/01/2000 - "Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis."
08/01/2008 - "The combination of genistin and ipriflavone prevents mammary tumorigenesis and modulates lipid profile."
01/30/2008 - "WITHDRAWN: The combination of genistin and ipriflavone prevents mammary tumorigenesis and modulates lipid profile."

01/01/2016 - "The present study aimed to assess the effects and mechanisms of genistin in the rat model of myocardial ischemia reperfusion injury. "
01/01/2016 - "Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway."
01/01/2016 - "These results presented here demonstrated that genistin enhanced the protective effect on the rats with myocardial ischemia reperfusion injury. "
01/01/2016 - "In the rat of myocardial ischemia/reperfusion (MI/R), it was found that genistin pretreatment reduced myocardial infarct size, improved the heart rate, and decreased creatine kinase (CK) and lactate dehydrogenase (LDH) levels in coronary flow. "

01/18/2006 - "However, equimolar oral administration of genistin did not induce thymus atrophy. "
04/01/2001 - "On the other hand, genistin prevented ovx-induced uterine atrophy only at a dose of 100 mg/kg, but did not block any other change of ovx rats at a dose of 50 or 100 mg/kg. These findings indicate that daidzin, glycitin, and genistin are effective in preventing bone loss and the former two compounds are effective in reversing the unfavorable changes of lipid metabolism in this model. "
01/18/2006 - "Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat."