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phenanthridone

coal tar derivative; structure given in first source

Also Known As:

6(5H)-phenanthridinone

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        phenanthridone: 12
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - phenanthridone: 12

Experts

1.	Ding, Qiang: 1 article (01/2018)
2.	Hang, Wei: 1 article (01/2018)
3.	Jian, Yong-Ping: 1 article (01/2018)
4.	Li, Dong-Dong: 1 article (01/2018)
5.	Li, Yu-Lin: 1 article (01/2018)
6.	Liu, Gang: 1 article (01/2018)
7.	Quan, Cheng-Shi: 1 article (01/2018)
8.	Shen, Xiang-Feng: 1 article (01/2018)
9.	Sun, Qian-Hui: 1 article (01/2018)
10.	Wang, Yi-Shu: 1 article (01/2018)

Related Diseases

1.	Lymphoma (Lymphomas) 09/01/2000 - "In contrast, 6(5H)-phenanthridinone failed to affect the doxorubicin toxicity in murine lymphoma cells, whereas it prevented the cytotoxicity of this drug in the human cell line. " 12/01/1997 - "Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells." 01/01/1994 - "In this study, we have investigated the action of 6(5H)-phenanthridinone, an isoquinoline derivative and one of the most potent PARP inhibitors described so far, on RDM4 murine lymphoma cells in culture. " 09/01/2000 - "Here, we evaluated the ability of the PARP inhibitor, 6(5H)-phenanthridinone, to modulate the antiproliferative activity of bleomycin, carmustin and doxorubicin in a murine (RDM4) and a human (U937) lymphoma cell lines. "
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/01/2002 - "2. This study investigated the effect of the PARP-1 inhibitors 6(5H)-phenanthridinone and benzamide as well as that of benzoic acid, an inactive analogue of benzamide, on development of experimental allergic encephalomyelitis (EAE) in rats. "
3.	Neoplasms (Cancer) 06/05/2007 - "Our results indicate that the phenanthridone skeleton in natural Amaryllidaceae alkaloids may be a significant common element for selectivity against cancer cells; furthermore, the configuration of the methoxy-side groups is responsible for higher binding affinity to the target protein/s thus making for a more efficient anti-cancer agent." 01/01/2018 - "Following the success of these natural products, in this review, twenty-six types of isoquinoline alkaloids (a total of 379 alkaloids), including benzyltetrahydroisoquinoline, aporphine, oxoaporphine, isooxoaporphine, dimeric aporphine, bisbenzylisoquinoline, tetrahydroprotoberberine, protoberberine, protopine, dihydrobenzophenanthridine, benzophenanthridine, benzophenanthridine dimer, ipecac, simple isoquinoline, pavine, montanine, erythrina, chelidonine, tropoloisoquinoline, azafluoranthene, phthalideisoquinoline, naphthylisoquinoline, lycorine, crinane, narciclasine, and phenanthridone, were summarized based on their cytotoxic and MDR reversing activities against various cancer cells. "
4.	Necrosis 01/01/2004 - "Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis." 11/01/2002 - "Both 6(5H)-phenanthridinone and benzamide attenuated development of EAE, reducing clinical score, neuroimmune infiltration and expression of inflammatory mediators such as inducible nitric oxide synthase, interleukin-1beta and -2, cyclooxygenase-2, tumour necrosis factor-alpha and interferon-gamma in the spinal cord of myelin-immunized rats. " 11/01/2002 - "In cultures of activated rat lymphocytes, 6(5H)-phenanthridinone and benzamide reduced the DNA-binding activity of NF-kappaB and AP-1 and transcription of pro-inflammatory cytokines such as interleukin-2, interferon-gamma and tumour necrosis factor-alpha. "
5.	Stupor 05/01/2008 - "The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 micromol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. "

Related Drugs and Biologics

1.	Poly(ADP-ribose) Polymerase Inhibitors
2.	isoquinoline
3.	benzamide
4.	Benzoic Acid (Potassium Benzoate)
5.	Interleukin-1beta (Interleukin 1 beta)
6.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
7.	Cyclooxygenase 2 (Cyclooxygenase-2)
8.	Amaryllidaceae Alkaloids
9.	Benzylisoquinolines
10.	Transcription Factor AP-1 (Transcription Factor AP 1)