lipoxin A4

01/01/2022 - "Conversely, treatment of mice with IFN-β accelerates clearance of bacteria, restores neutrophil phagocytosis, promotes neutrophil apoptosis and efferocytosis, and accelerates resolution of airway inflammation with concomitant increases in 15-epi-LXA4 and RvD1 production in the lungs. "
01/01/2021 - "We conducted a randomized, placebo-controlled, parallel-group Phase 1 clinical trial to determine the safety and preliminary efficacy of an LXA4 analog in patients with gingival inflammation. "
01/01/2020 - "Treatment of mice with 15-epi-LXA4 or 17-epi-RvD1 at the peak of inflammation accelerates clearance of bacteria, blunts PMN accumulation, and promotes PMN apoptosis and efferocytosis, thereby facilitating resolution of E. "
01/01/2023 - "In this study, LPS was used to establish the inflammation model of pregnant mice and HTR8 cells, and LXA4 and exosome treatment were carried out to observe the fetal membranes' tissue repair. "
01/01/2023 - "Thus, in this study, we analyze the role of p65/NFκB, and FoxO1 in CFs inflammation induced by HG, evaluating the anti-inflammatory properties of LXA4. "

08/02/2023 - "Treatment with LXA4 receptor antagonist attenuated the effect of M2-Exos on PMNs and lung injury. "
10/01/2022 - "Our results indicated that exogenous administration of LXA4 could reduce the degree of lung injury in ARDS rats and inhibit the release of pro-inflammatory factors TNF-α and IL-1β in lung tissue homogenate. "
10/01/2022 - "The Effect and Mechanism of Lipoxin A4 on Neutrophil Function in LPS-Induced Lung Injury."
01/01/2019 - "Downregulation of TNF-α signals by AT-Lipoxin A4 may be a significant mechanism in the attenuation of SAP-associated lung injury."
01/01/2019 - "We used western blot, polymerase chain reaction (PCR), and immunofluorescence to investigate the downregulation of TNF-α signals in cellular and animal models of SAP-associated lung injury following AT-Lipoxin A4 intervention. "

11/01/2013 - "Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2."
09/01/2020 - "Lipoxin A4 protects rat skin flaps against ischemia-reperfusion injury through inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress."
01/01/2017 - "Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats."
01/01/2016 - "Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner."
12/15/2007 - "Lipoxin A4 and annexin-1 failed to prevent reperfusion injury in IL-10-deficient mice. "

01/01/2019 - "Lipoxin A4 ameliorates renal ischaemia-reperfusion-induced acute lung injury in rats."
01/01/2021 - "Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways."
01/01/2018 - "Lipoxin A4 attenuates LPS-induced acute lung injury via activation of the ACE2-Ang-(1-7)-Mas axis."
08/01/2015 - "Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4."
01/01/2013 - "Thus, lipoxin A4 may provide a potential therapeutic approach for acute lung injury."

05/29/2019 - "Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection."
01/01/2018 - "berghei-infected (LXA4  administered 1 h before infection and daily, from days 0 to 5 postinfection), LXA4 - and LXA4 receptor antagonist BOC-2-pretreated P. "
01/01/2017 - "Conversely, administration of exogenous LXA4 to Alox5-/- mice made them more susceptible to infection thus mimicking wild-type animals. "
01/01/2016 - "In contrast, lung basal expression of the LXA4 receptor Alx/Fpr2 was higher in C.B-17 relative to C57BL/6 mice, and after Cne infection, Alx/Fpr2 expression was significantly increased in only C.B-17 mice. "
04/01/2014 - "15-Epi-lipoxin A4 has protective and resolving effects in experimental models of infection. "