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5-deazaaminopterin

structure given in first source

Also Known As:

L-Glutamic acid, N-(4-(((2,4-diaminopyrido(2,3-d)pyrimidin-6-yl)methyl)amino)benzoyl)-

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Aminopterin: 248
        5-deazaaminopterin: 2

Related Diseases

1.	Neoplasms (Cancer) 10/15/1988 - "Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models."
2.	Sarcoma 180 10/15/1988 - "The extent of polyglutamylation of 5-deazaaminopterin and 5-deazamethotrexate and their 5-alkyl derivatives in Sarcoma 180 cells was substantially less compared to aminopterin and equivalent to methotrexate. "
3.	Arthritis (Polyarthritis) 01/31/1997 - "2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	5-deazamethotrexate
3.	Collagen Type II (Type II Collagen)
4.	Aminopterin
5.	5,10-dideazaaminopterin