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phenylalanylglycine

RN given refers to (DL)-isomer

Also Known As:

L-phenylalanylglycine; Phe-GLy

Networked: 21 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - phenylalanylglycine: 21

Experts

1.	Palmenberg, Ann C: 2 articles (04/2017 - 10/2015)
2.	Bilimoria, Darius: 1 article (12/2017)
3.	Black, Karen M: 1 article (12/2017)
4.	Delpeut, Sébastien: 1 article (12/2017)
5.	Ha, Michael N: 1 article (12/2017)
6.	Jiang, Yiqun: 1 article (12/2017)
7.	Li, Yanju: 1 article (12/2017)
8.	Lin, Liang-Tzung: 1 article (12/2017)
9.	Noyce, Ryan S: 1 article (12/2017)
10.	Plemper, Richard K: 1 article (12/2017)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2000 - "The antitumor efficacy of the conjugate of doxorubicin (DXR) and carboxymethylpullulan (CMPul) with Phe-Gly spacer (CMPul-FG-DXR) was evaluated using murine tumor models and compared with that of DXR. " 09/01/2016 - "ADAM10 enzyme activity was determined using a tumor necrosis factor‑α converting enzyme (α‑secretase) activity assay kit, and NEP enzyme activity was measured with a fluorometric assay based on the generation of free dansyl‑D‑Ala‑Gly from N-dansyl-Ala-Gly-D-nitro-Phe-Gly, the substrate of NEP. " 04/16/2014 - "A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in human cancer cells. " 01/01/2000 - "The present experiments tested moxonidine for ability to synergize with morphine, deltorphin II, and DAMGO (Tyr-D-Ala-NMe-Phe-Gly(ol)) to inhibit substance P-elicited nociceptive behavior in Institute of Cancer Research mice. "
2.	Ganglion Cysts (Ganglion) 01/01/2004 - "The aim of the present study was to investigate the effect of a micro-opioid receptor agonist DAMGO (Tyr-d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for micro-opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2017 - "The aim of this study was to investigate the antimetastatic effect of Asn-Phe-Gly-Lys (NFGK), a tetrapeptide derived from bovine hemoglobin pepsin hydrolysate, on human pancreatic cancer cell line MIAPaCa-2. " 12/01/2017 - "Bovine Hemoglobin Derived Peptide Asn-Phe-Gly-Lys Inhibits Pancreatic Cancer Cells Metastasis by Targeting Secreted Hsp90α."
4.	Infections 12/01/2017 - "Three decades ago, the small hydrophobic peptide Z-d-Phe-l-Phe-Gly (FIP) was shown to block MeV infections and syncytium formation in monkey kidney cell lines. " 02/01/2015 - "We used RNA interference (RNAi) to deplete cells of either Nup214 or Nup358, the two major Phe-Gly (FG) repeat nucleoporins localized on the cytoplasmic side of the NPC, and evaluated the impact on hexon binding and AdV infection. " 03/01/1992 - "When anti-MV serum or carbobenzoxy-D-Phe-L-Phe-Gly, a synthetic oligopeptide known to inhibit MV-induced fusion, was added 24 hr after infection, the inhibition of T cell proliferation was reversed in a dose-dependent manner. " 04/15/2017 - "The RNA rhinoviruses (RV) encode 2A proteases (2Apro) that contribute essential polyprotein processing and host cell shutoff functions during infection, including the cleavage of Phe/Gly-containing nucleoporin proteins (Nups) within nuclear pore complexes (NPC). "
5.	Neuroblastoma 05/08/1985 - "The binding of alkylendiamide dimers of the three N-terminal residues of [D-Ala2,D-Leu5]enkephalin (DADL) to rat brain and Ng108-15 neuroblastoma-glioma cell membranes was compared with that of DADL, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO) and morphiceptin. " 05/01/1993 - "In membranes from SH-SY5Y human neuroblastoma cells differentiated with retinoic acid, the mu-selective agonist Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) inhibited cAMP formation with an IC50 of 26 nM. Two separate antibodies raised against distinct regions of the Go alpha sequence attenuated the effect of DAMGO by 50-60%, whereas antibodies to Gi alpha 1,2 or Gi alpha 3 reduced the mu-opioid signal insignificantly or to a lesser extent. " 10/23/1995 - "The effects of the mu opioid receptor agonists, morphine and Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol (DAGO), the delta opioid receptor agonist, Tyr-D-Pen-Gly-Phe-D-penicillamine (DPDPE) and the kappa-opioid receptor agonist, dynorphin A-(1-13) on the whole-cell K+ currents (IK) of cultured mouse DRG neurons and neuroblastoma X DRG neuron hybrid F11 cells were studied. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	carboxymethylpullulan- phenylglycyl- doxorubicin conjugate
3.	carboxymethylpullulan
4.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
5.	alanylglycine
6.	Proteins (Proteins, Gene)
7.	Messenger RNA (mRNA)
8.	Opioid Receptors (Opioid Receptor)
9.	Pepsin A (Pepsin)
10.	Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1.	Intradermal Injections
2.	Analgesia