Tn antigen

10/10/2022 - "Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties."
10/05/2022 - "Such a nanovector could specifically target tumor cells overexpressing the Tn antigen to promote the cellular uptake. "
05/24/2022 - "These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also known as the Tn antigen, expressed in a variety of tumor cell types. "
10/01/2021 - "Surface expression of Tn-antigen was identified across several cancers. "
11/29/2020 - "We evaluated the correlation of Tn antigen expression by immunohistochemistry with mismatch-repair (MMR) status, tumor-infiltrating lymphocytes, tumor cell PD-L1 expression, and clinicopathological characteristics in 507 CRC patients. "

11/01/2023 - "The expression of Tn antigen was induced in two breast cancer cell lines by deleting T-synthase or Cosmc, both of which are required for normal O-glycosylation. "
01/01/2020 - "We deleted the Cosmc gene in two breast cancer cell lines (MCF7, T47D) using the CRISPR/Cas-9 system and then measured the expression levels of Tn antigen. "
09/01/2005 - "We aimed to investigate the causes of the expression of Tn antigen in the Tn-rich MCF-7 breast cancer cell line focusing on the first step of the O-glycosylation process. "
08/01/2005 - "We concluded that the lack of polymorphic MUC1 expression with Tn antigen is one characteristic related to aggressive breast cancer."
03/01/2001 - "Moreover, the findings signified a potential value for a negative or low Tn antigen expression in prognostic stratification of breast carcinomas."

12/07/2022 - "Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions."
05/01/2020 - "The Tn antigen is of interest because it is expressed by several adenocarcinomas, but not normal cells. "
04/01/1991 - "Despite its specificity, H17 does not react with TA3-Ha, a mouse mammary adenocarcinoma, known to express the Tn antigen (GalNAc alpha-O-Ser/Thr). "
07/01/1991 - "Tn antigen was observed throughout adenocarcinomas, squamous and small cell carcinomas in a relatively weak manner. "
06/01/1992 - "The antibody Tn5 (similar to BRIC111) was shown to be specific for human erythrocyte Tn antigen, whereas Tn56 reacted strongly with different glycoproteins carrying O-linked GalNAc alpha- residues, and was strongly bound to the murine adenocarcinoma cell line Ta3-Ha. "

09/23/2010 - "To enable experimental approaches to study interactions of the Tn antigen with the immune system and analyze anti-Tn antibody responses in infection or disorders, we generated a Tn-expressing resource that can be used for high-throughput screening. "
10/01/2013 - "parvum that contain the Tn antigen induce immune responses upon infection. "
10/17/2023 - "parvum infection in vitro as did glycan-binding proteins specific for the Tn antigen (GalNAc-α1-S/T). "
10/01/2013 - "These studies reveal that specific anti-glycopeptide antibodies that recognise the Tn antigen may be useful diagnostically and in defining the roles of parasite glycoconjugates in infections. "
01/01/2018 - "The Tn antigen (GalNAcα1-Ser/Thr) is an O-glycan essential for these processes, as Tn-specific lectins and a Tn-specific monoclonal antibody block attachment to and infection of host cells in vitro. "

07/01/2021 - "The Tn antigen is highly specific for carcinomas, and this is the first time that such structure is targeted for drug delivery. "
08/01/2011 - "Here, we investigated the mechanism of action of a Tn antigen-specific chimeric mAb (Chi-Tn), which binds selectively to a wide variety of carcinomas, but not to normal tissues, in both humans and mice. "
06/01/2001 - "O-glycosylation in Echinococcus granulosus: identification and characterization of the carcinoma-associated Tn antigen."
01/01/1999 - "Asialo TF and Tn antigen were not observed on the surface of carcinoma cells of any type. "
05/01/1996 - "The expression of the Tn antigen detected by HB-Tn1 and B1.1 was found in 17 (20%) and 19 (23%) of the 83 invasive carcinomas, respectively, but was not found in the 36 normal squamous epithelia, 22 severe dysplasias, or 24 carcinomas in situ. "