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tiacrilast
structure given in first source
Also Known As:
3-(6-(methylthio)-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid; Ro 223747; Ro-22-3747; 2-Propenoic acid, 3-(6-(methylthio)-4-oxo-3(4H)-quinazolinyl)-, (E)-
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
tiacrilast: 4
Related Diseases
1.
Atopic Dermatitis (Atopic Eczema)
01/01/1993 - "
Topical tiacrilast, a potent mast cell degranulation inhibitor, does not improve adult atopic eczema.
"
01/01/1993 - "
Since mast cells and their mediators are possibly involved in atopic eczema, we have studied a topically applied 3% hydrogel formulation of tiacrilast against vehicle in a multicenter, double-blind, placebo-controlled trial.
"
2.
Psoriasis (Pustulosis Palmaris et Plantaris)
01/01/1995 - "
A total of 31 patients with plaque-type psoriasis were evaluated after treatment with a 3% Tiacrilast hydrogel and hydrogel alone, in a double-blind, placebo-controlled, within-patient comparative study.
"
3.
Immediate Hypersensitivity
06/01/1986 - "
Tiacrilast (Ro 22-3747) is an allergic mediator release inhibitor which has demonstrated potent oral activity in two IgE-mediated animal models of immediate hypersensitivity: the rat passive cutaneous anaphylaxis test (ID50 of 0.65 mg/kg) and a model in which anaphylactic bronchospasm is induced in passively sensitized rats (ID50 of 0.022 mg/kg).
"
4.
Contact Dermatitis (Eczema, Contact)
01/01/1990 - "
Effect of tiacrilast, a mast cell mediator-release inhibitor, on murine experimental contact dermatitis.
"
01/01/1990 - "
The effect of tiacrilast, a mast cell mediator-release inhibitor, was studied in dinitrofluorobenzene-induced allergic and croton oil- or dimethyl sulfoxide-induced irritant murine contact dermatitis.
"
5.
Bronchial Spasm
06/01/1986 - "
Tiacrilast (Ro 22-3747) is an allergic mediator release inhibitor which has demonstrated potent oral activity in two IgE-mediated animal models of immediate hypersensitivity: the rat passive cutaneous anaphylaxis test (ID50 of 0.65 mg/kg) and a model in which anaphylactic bronchospasm is induced in passively sensitized rats (ID50 of 0.022 mg/kg).
"
Related Drugs and Biologics
1.
Hydrogels
2.
Irritants (Vesicants)
3.
Immunoglobulin E (IgE)
4.
Dinitrofluorobenzene
5.
Dimethyl Sulfoxide (DMSO)
6.
Croton Oil
Related Therapies and Procedures
1.
Aftercare (After-Treatment)