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2- (3,4- dimethoxyphenyl)- 3- fluoroallylamine
structure & RN from first source; RN given refers to (E)-isomer
Also Known As:
2-DLPFA; MDL 72145; MDL-72145
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Allylamine: 127
2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: 3
Hydrocarbons: 1713
Acyclic Hydrocarbons
Alkenes: 265
Allyl Compounds: 7
Allylamine: 127
2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: 3
Related Diseases
1.
Parkinson Disease (Parkinson's Disease)
01/01/1986 - "
The potential of a new, potent, irreversible and selective inhibitor of monoamine oxidase type B, (E)-2-(3,4-dimethoxyphenyl)-3-fluorallyamine (MDL 72145), to augment the effects of L-DOPA in an animal model which reproduces the biochemical defect of Parkinson's disease has been evaluated.
"
01/01/1986 - "
The data provide no reason to suppose that MDL 72145 would be very different in clinical use from L-deprenyl which is both effective and well-tolerated as an adjunct to the L-DOPA-based therapy of Parkinson's disease.
"
2.
Nematode Infections
01/01/1996 - "
Both results suggest that MDL 72145 might be a chemical lead compound for the design of new chemotherapeutic agents against nematode infections.
"
3.
Hypothermia
11/01/1985 - "
L-Deprenyl differed from MDL 72145 in that short term treatment with this drug caused positive effects in the "Behavioural Despair" test, reversal of reserpine hypothermia, indirect sympathomimetic stimulation of blood pressure and heart rate in the pithed rat and ipsilateral rotation in rats with unilateral nigro-striatal lesions.
"
Related Drugs and Biologics
1.
Selegiline (E250)
2.
Sympathomimetics (Sympathomimetic Amines)
3.
Reserpine (Serpasil)
4.
Monoamine Oxidase (MAO)
5.
Levodopa (L Dopa)
Related Therapies and Procedures
1.
Therapeutics