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gabapentin (Neurontin)

can be viewed as a cyclohexane-GABA; an oral medication for add-on therapy in the treatment of partial seizures in adult epilepsy; inhibits dopamine release from rabbit caudate nucleus

Also Known As:

Neurontin; 1-(aminomethyl)cyclohexaneacetic acid; Apo-Gabapentin; Apotex brand of gabapentin; Aventis brand of gabapentin; Gabapentin Hexal; Gabapentin Stada; Gabapentin-ratiopharm; Hexal brand of gabapentin; Novo-Gabapentin; Novopharm brand of gabapentin; PMS-Gabapentin; Parke Davis brand of gabapentin; Pfizer brand of gabapentin; Pharmascience brand of gabapentin; Stadapharm brand of gabapentin; Warner-Lambert brand of gabapentin; ratiopharm brand of gabapentin

Networked: 2532 relevant articles (579 outcomes, 656 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Luszczki, Jarogniew J: 13 articles (03/2015 - 10/2003)
2.	Gilron, Ian: 13 articles (02/2015 - 01/2005)
3.	Loprinzi, Charles L: 13 articles (11/2014 - 05/2003)
4.	Ono, Hideki: 13 articles (01/2014 - 12/2004)
5.	Granados-Soto, Vinicio: 12 articles (02/2015 - 01/2003)
6.	Guttuso, Thomas: 12 articles (10/2014 - 02/2003)
7.	Tanabe, Mitsuo: 11 articles (12/2009 - 12/2004)
8.	Moore, R Andrew: 10 articles (01/2015 - 08/2008)
9.	Sweeney, Michael: 9 articles (10/2015 - 01/2012)
10.	Eisenach, James C: 9 articles (10/2014 - 03/2007)

Related Diseases

1.	Pain (Aches) 11/26/2002 - "Patients whose symptoms included pain benefited most from gabapentin. " 11/01/2014 - "There is evidence to suggest that gabapentin is safe and effective in reducing opioid consumption and pain scores at optimal doses of 600-900 mg orally administered preoperatively. " 03/01/2008 - "After surgery, the patient continued to experience pain; however, his pain resolved completely after several weeks of receiving gabapentin 600 mg 3 times/day. " 04/01/2002 - "Of five patients with sensory deficits who tolerated gabapentin therapy, three showed marked improvement of their sensory deficits associated with pain alleviation. " 01/01/2015 - "Finally, the pain was successfully relieved by gabapentin as an adjuvant to tramal. "
2.	Neuralgia (Stump Neuralgia) 06/01/2004 - "Ease of use and broad therapeutic range, in addition to demonstrated efficacy, make gabapentin the drug of choice for most neuropathic pain disorders. " 01/01/2012 - "The anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. " 09/01/2002 - "The anticonvulsant gabapentin has proven effective for neuropathic pain in three large placebo-controlled clinical trials. " 01/01/2014 - "Second tier evidence, with potentially important residual biases, showed that gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions. " 09/01/2012 - "The results of this study show that gabapentin is effective in acute herpetic neuralgia in different doses with 600 mg/day being the more appropriate dose in terms of safety and efficacy."
3.	Seizures (Seizure) 06/01/2000 - "The objective of this study was to determine the efficacy of gabapentin as adjunctive therapy in doses required to achieve the most effective seizure control. " 01/01/2004 - "The preliminary findings of this study suggest that gabapentin is very effective against tonic-clonic seizures in alcohol withdrawal syndrome. " 08/01/2006 - "More gabapentin patients reported moderate to marked improvement in seizure frequency and intensity/duration of each seizure than placebo patients. " 08/01/2006 - "Gabapentin 1200 mg/day and 1800 mg/day significantly reduced the frequency of refractory seizures compared to placebo. " 12/01/1995 - "Gabapentin used as an add-on AED significantly reduced the frequency of partial seizures and secondarily generalized tonic-clonic seizures in three large double-blind, placebo-controlled, parallel-group clinical trails. "
4.	Postherpetic Neuralgia 01/01/2013 - "Gabapentin and tricyclic antidepressant are effective in postherpetic neuralgia. " 11/01/2001 - "Thus, this study confirms the role of gabapentin as an efficacious and well-tolerated treatment for postherpetic neuralgia." 04/01/1996 - "Gabapentin as a novel treatment for postherpetic neuralgia." 09/01/2012 - "The efficacy of once-daily gastroretentive gabapentin for the management of postherpetic neuralgia has been demonstrated in placebo-controlled clinical studies. " 12/01/2013 - "Safety and efficacy of once-daily gastroretentive gabapentin in patients with postherpetic neuralgia aged 75 years and over."
5.	Epilepsy (Aura) 09/01/1997 - "Although the spectrum of efficacy of gabapentin remains to be determined, it is likely to have a major beneficial impact on the treatment of childhood epilepsy." 01/12/2005 - "Gabapentin at a dosage of 1200 mg/d is safe and effective in treatment of epilepsy." 01/12/2005 - "To assess the safety and efficacy of gabapentin in treatment of refractory epilepsy. " 12/01/2003 - "Limited efficacy of gabapentin in severe therapy-resistant epilepsies of learning-disabled patients." 10/01/2014 - "The study was aimed to prepare and evaluate gabapentin loaded albumin nanoparticles and to find out their effectiveness in treating epilepsy. "

Related Drugs and Biologics

1.	pregabalin (Lyrica)
2.	lamotrigine (Lamictal)
3.	Carbamazepine (Tegretol)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	topiramate (Topamax)
6.	Amitriptyline (Elavil)
7.	Opioid Analgesics (Opioids)
8.	tiagabine (Gabitril)
9.	Valproic Acid (Valproate, Semisodium)
10.	Morphine (MS Contin)

Related Therapies and Procedures

1.	Analgesia
2.	Drug Therapy (Chemotherapy)
3.	Relaxation Therapy
4.	Hysterectomy
5.	Psychology Biofeedback (Biofeedback)