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bermoprofen (AD 1590)
structure given in first source
Also Known As:
AD 1590
; 2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic acid; AD-1590
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Dibenzoxepins
bermoprofen: 6
Related Diseases
1.
Fever (Fevers)
03/01/1984 - "
AD-1590 produced a dose-related inhibition of the LPS-fever at oral doses of 0.1 mg kg-1 or more (ED50 = 0.089 mgg kg-1).
"
12/01/1984 - "
A significant antipyretic effect of AD-1590 on LPS-fever was found when AD-1590 (4 micrograms/rabbit) was injected into the PO/AH regions.
"
12/01/1984 - "
AD-1590 (0.1 mg/kg i.v.) prevented the fever caused by LP as well as LPS, but did not prevent the fever by PGE2 (100 ng/rabbit) injected into the preoptic anterior hypothalamic (PO/AH) regions.
"
03/01/1984 - "
These results suggest that AD-1590 shows a potent antipyretic activity in the rabbit and monkey and is a potent antagonist of LPS-fever.
"
03/01/1984 - "
AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits.
"
2.
Inflammation (Inflammations)
07/01/1988 - "
Effect of AD-1590 on allergic inflammations was investigated.
"
07/01/1988 - "
[Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats].
"
07/01/1988 - "
These results demonstrate that in allergic inflammation, the pharmacological properties of AD-1590 are somewhat different from those of other NSAID and different from those of prednisolone and cyproheptadine.
"
01/01/1983 - "
AD-1590 showed the potent inhibitory activity on acute and subacute inflammation such as carrageenin hind paw edema (oral ED50 = 1.35 mg/kg), acetic acid-induced increased vascular permeability (0.205 mg/kg), UV-erythema (0.295 mg/kg) and felt pellet-induced granuloma formation (1.7 mg/kg), and its potency was on the whole 2 to 3 times that of indomethacin.
"
3.
Erythema
06/01/1988 - "
Inhibitory potency of AD-1590 on UV-erythema and increased vascular permeability induced by acetic acid in male rats was about 2.1 and 2.3 times, respectively, that of indomethacin.
"
06/01/1988 - "
Authors have reported that the oral potency ratio of AD-1590 to indomethacin varies with the animal models employed; the ratio is 4, 2.3 and 31 in the tests of acetic acid-induced vascular permeability (male mice), carrageenan hind paw edema (male rats) and UV-erythema (female guinea pigs), respectively.
"
01/01/1983 - "
AD-1590 showed the potent inhibitory activity on acute and subacute inflammation such as carrageenin hind paw edema (oral ED50 = 1.35 mg/kg), acetic acid-induced increased vascular permeability (0.205 mg/kg), UV-erythema (0.295 mg/kg) and felt pellet-induced granuloma formation (1.7 mg/kg), and its potency was on the whole 2 to 3 times that of indomethacin.
"
4.
Edema (Dropsy)
06/01/1988 - "
Authors have reported that the oral potency ratio of AD-1590 to indomethacin varies with the animal models employed; the ratio is 4, 2.3 and 31 in the tests of acetic acid-induced vascular permeability (male mice), carrageenan hind paw edema (male rats) and UV-erythema (female guinea pigs), respectively.
"
01/01/1983 - "
AD-1590 showed the potent inhibitory activity on acute and subacute inflammation such as carrageenin hind paw edema (oral ED50 = 1.35 mg/kg), acetic acid-induced increased vascular permeability (0.205 mg/kg), UV-erythema (0.295 mg/kg) and felt pellet-induced granuloma formation (1.7 mg/kg), and its potency was on the whole 2 to 3 times that of indomethacin.
"
5.
Hyperthermia
12/01/1984 - "
AD-1590 (0.4 mg/kg i.v.) did not produce anti-pyretic activity against 2,4-dinitrophenol-hyperthermia; the monoamine levels in the brain were not affected with AD-1590 (10 mg/kg p.o.).
"
12/01/1985 - "
When injected intracerebroventricularly, AD-1590 dose-dependently inhibited the hyperthermia caused by arachidonic acid given by the same route; its ED50 was 1.6 micrograms compared with about 35 micrograms for indomethacin.
"
Related Drugs and Biologics
1.
Indomethacin (Indometacin)
2.
Antipyretics
3.
Pyrogens
4.
Acetic Acid (Vinegar)
5.
Carrageenan
6.
2,4-Dinitrophenol (2,4 Dinitrophenol)
7.
Arachidonic Acid (Vitamin F)
8.
Dinoprostone (PGE2)
9.
Silver Nitrate
10.
Prednisolone (Predate)
Related Therapies and Procedures
1.
Intravenous Administration