peptide E (adrenal medulla)

kappa opiate receptor agonist; 25-amino acid opioid peptide which when cleaved at the sole double basic (Lys-Arg) typical processing site generates the amino-terminal fragment BAM 18 & the carboxy-terminal fragment Leu-enkephalin; structure given in first source;

Also Known As:

opioid peptide E; peptide E; peptide E proenkephalin; proenkephalin peptide E

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Enkephalins: 1042
        peptide E (adrenal medulla): 13
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Enkephalins: 1042
        peptide E (adrenal medulla): 13

Experts

1.	Edwards, Adam B: 1 article (10/2020)
2.	Knuckey, Neville W: 1 article (10/2020)
3.	Mastaglia, Frank L: 1 article (10/2020)
4.	Meloni, Bruno P: 1 article (10/2020)
5.	Diedrichs-Möhring, Maria: 1 article (01/2020)
6.	Wildner, Gerhild: 1 article (01/2020)
7.	Burgess, Diane J: 1 article (10/2019)
8.	Jiang, Kuan: 1 article (10/2019)
9.	Lu, Linwei: 1 article (10/2019)
10.	Lu, Weiyue: 1 article (10/2019)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 02/24/2005 - "In this study, we evaluated the antitumor activity of paclitaxel (PTX) conjugated with a bicyclic peptide E[c(RGDyK)](2) (RGD) in a metastatic breast cancer cell line (MDA-MB-435). "
2.	Neoplasms (Cancer) 10/01/2019 - "Here, we report that display of a tumor targeting cyclic RGD peptide (e.g. " 04/01/2015 - "Recent experimental work has shown that a delivery construct consisting of an ELP-therapeutic peptide (e.g., the c-Myc-inhibitory peptide, or the p21(WAF1/CIP1)-derived peptide), as well as ELP-small molecule drugs (e.g., doxorubicin, paclitaxel), can be thermally targeted to accumulate in tumors and diminish their growth. "
3.	Autoimmune Diseases (Autoimmune Disease) 01/01/2020 - "Therefore, autoimmune diseases targeting these organs were hard to explain, unless a T cell is activated by an environmental peptide (e.g. " 12/01/2001 - "Contrary to this paradigm, we report here that transgenic mice lacking MHC class I expression and expressing an MHC class II I-A(b) molecule that presents only a single peptide (E alpha 52-68) spontaneously develops peripheral nervous system-specific autoimmune disease with many of the histopathological features found in experimental allergic neuritis. "
4.	Coinfection 02/15/1997 - "Two samples (1.3%) reacted to peptide E; however, both were also reactive against the B peptide, suggesting co-infection with B and E subtypes. "
5.	Virus Diseases (Viral Diseases) 06/01/2010 - "To observe the ability of dengue virus type 1-4 envelope domain III fusion protein to inhibit virus infection and analyze the neutralizing ability of polyclonal antibodies against rE III. After being connected by linker peptide, E III protein of Dengue virus serotypes 1-4 were expressed in E coli BL21 (DE3) then purified. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Peptides (Polypeptides)
3.	Leptin
4.	Glutamic Acid (Glutamate)
5.	Endothelins (Endothelin)
6.	Steroids
7.	Proteins (Proteins, Gene)
8.	Protamines (Protamine Sulfate)
9.	Insulin (Novolin)
10.	Fibrinogen (Factor I)