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5,5'- difluoro- 1,2- bis(2- aminophenoxy)ethane- N,N,N',N'- tetraacetic acid
structure given in first source
Also Known As:
1,2-bis(2-amino-5-fluorophenoxyl)ethane-N,N,N',N'-tetraacetic acid; 5,5'-F2-BAPTA; 5,5'-FBAPTA; 5F-BAPTA; Glycine, N,N'-(1,2-ethanediylbis(oxy(5-fluoro-2,1-phenylene)))bis(N-(carboxymethyl))
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Diamines: 518
Ethylenediamines: 7
Egtazic Acid: 365
5,5'-difluoro-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: 6
Carboxylic Acids: 973
Acyclic Acids
Acetates: 4994
Egtazic Acid: 365
5,5'-difluoro-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: 6
Related Diseases
1.
Ischemia
05/01/1990 - "
Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion.
"
05/01/1990 - "
Although the nonlinear response of 5F-BAPTA to [Ca2+] leads to underestimation of the true time-averaged [Ca2+]i, the measured alterations of intracellular Ca2+ homeostasis during ischemia are large compared with the likely errors in quantification.
"
07/01/1996 - "
We used ion-selective electrodes, nuclear magnetic resonance spectroscopy, and the four-electrode method to perform four series of experiments in the isolated blood-perfused rabbit heart loaded with 5F-BAPTA during 30 to 35 minutes of no-flow ischemia.
"
05/01/1990 - "
Developed pressure recovers to only 50% of control values during reflow, indicating that the presence of 5F-BAPTA in the cytosol does not protect against stunning, at least when the extracellular calcium concentration has been raised to 8 mM. We conclude that 5F-BAPTA provides useful measurements that reveal that time-averaged [Ca2+]i rises during ischemia and returns to control levels soon after reperfusion.
"
09/01/1991 - "
To investigate excitation-contraction coupling in stunned myocardium, intracellular free calcium concentration [( Ca2+]i) was measured before and after ischemia in perfused hearts using gated 19F NMR and the Ca2+ indicator 5F-BAPTA.
"
2.
Myocardial Stunning (Stunned Myocardium)
05/01/1990 - "
To elucidate the mechanism of contractile dysfunction in postischemic ("stunned") myocardium, time-resolved measurements of intracellular free Ca2+ concentration ([Ca2+]i) were made using gated 19F nuclear magnetic resonance in seven perfused ferret hearts loaded with the fluorinated Ca2+ indicator 5F-BAPTA.
"
09/01/1991 - "
To investigate excitation-contraction coupling in stunned myocardium, intracellular free calcium concentration [( Ca2+]i) was measured before and after ischemia in perfused hearts using gated 19F NMR and the Ca2+ indicator 5F-BAPTA.
"
3.
Ventricular Fibrillation
08/01/1989 - "
We explored the role of intracellular free calcium in the pathophysiology and pathogenesis of ventricular fibrillation in perfused ferret hearts loaded with the Ca2+ indicator 5F-BAPTA.
"
4.
Contracture
01/01/1990 - "
Reperfusion with oxygenated perfusate shortly after peak contracture development resulted in a return of [Cai] to its preischemic level, resynthesis of creatine phosphate, no significant enzyme release, and no substantial loss of 5F-BAPTA from the heart.
"
Related Drugs and Biologics
1.
Indicators and Reagents (Reagents)
2.
Calcium
3.
Phosphocreatine (Neoton)
4.
Enzymes
Related Therapies and Procedures
1.
Ion-Selective Electrodes (Ion-Selective Electrode)
2.
Electrodes (Electrode)