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5-azacytosine

structure given in first source

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Cytosine: 1880
        5-azacytosine: 8

Experts

1.	Daifuku, Richard: 1 article (01/2018)
2.	Grimes, Sheila: 1 article (01/2018)
3.	Stackhouse, Murray: 1 article (01/2018)
4.	Krečmerová, Marcela: 1 article (05/2012)
5.	Otmar, Miroslav: 1 article (05/2012)
6.	Lyko, Frank: 1 article (07/2008)
7.	Stresemann, Carlo: 1 article (07/2008)
8.	Cappellacci, Loredana: 1 article (12/2003)
9.	Montgomery, John A: 1 article (12/2003)
10.	Secrist, John A: 1 article (12/2003)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2003 - "Synthesis and anti-cancer activity of some novel 5-azacytosine nucleosides." 01/01/2018 - "However, it suffers from a similar short half-life as other DNA methyltransferase inhibitors with a 5-azacytosine base, which is problematic for nucleosides that primarily target tumor cells in S phase. " 05/01/2012 - "Considering the potential pharmaceutical applications, 5-azacytosine and 5,6-dihydro-5-azacytosine appear to be so far the most effective cytosine mimics for the design of novel antiviral and anti-tumor drug candidates." 07/01/2008 - "The cytosine analogues 5-azacytosine (azacytidine) and 2'-deoxy-5-azacytidine (decitabine) are the currently most advanced drugs for epigenetic cancer therapies. "
2.	Stomach Ulcer (Gastric Ulcer) 01/15/1986 - "Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives."
3.	Pancreatitis 01/15/1986 - "Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives."
4.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 05/01/2012 - "This review summarizes the basic milestones of the research of 5-azacytosine nucleosides chronologically from their discovery and anticancer activity identification, through to subsequent unveiling of their mechanism of action based on DNA hypomethylation and tumor-suppressor gene reactivation, to the final US FDA approval of 5-azacytidine (Vidaza(®)) and 2'-deoxy-5-azacytidine (Dacogen(®)) for the treatment of myelodysplastic syndromes. "
5.	Infections 02/01/1990 - "When added 2 or more h after CEM cells were infected with HIV-1, both 5-azacytosine derivatives were less effective than they were when added at the time of infection. "

Related Drugs and Biologics

1.	Azacitidine (5 Azacytidine)
2.	Nucleosides
3.	DNA (Deoxyribonucleic Acid)
4.	Decitabine
5.	Methyltransferases
6.	Cytosine
7.	ADP Ribose Transferases (ADP Ribosyltransferase)
8.	Proteins (Proteins, Gene)
9.	Histones (Histone)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Therapeutics