peptidyl-Lys metalloendopeptidase

from Lysobacter enzymogenes; cleaves at the carboxyl side of lysine residues; active at pH 9;endoproteinase Lys-C (EC 3.4.99.30) was combined with EC 3.4.24.20 in 1992 Enzyme Nomenclature

Also Known As:

LysC protease; aspzincin; endopeptidase lys-C; endoprotease Lys-C; endoproteinase Lys-C

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        peptidyl-Lys metalloendopeptidase: 6
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        peptidyl-Lys metalloendopeptidase: 6

Experts

1.	Liu, Xiaohui: 1 article (09/2007)
2.	Shen, Huali: 1 article (09/2007)
3.	Yang, Pengyuan: 1 article (09/2007)
4.	Zhou, Wei: 1 article (09/2007)
5.	Zhou, Xinwen: 1 article (09/2007)
6.	Bikker, Floris J: 1 article (08/2002)
7.	Bolscher, Jan G M: 1 article (08/2002)
8.	Ligtenberg, Antoon J M: 1 article (08/2002)
9.	Mollenhauer, Jan: 1 article (08/2002)
10.	Nazmi, Kamran: 1 article (08/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/15/1989 - "Schwartz, Cancer Res., 49: 7010-7014, 1989), all cell lines studied contained a substantial amount of the intracellular NPY in the form of the unprocessed propeptide, 57% (range, 33-72%) as characterized by both gel filtrations (32 experiments in 8 cell lines) and "in vitro conversion" with endoproteinase Lys-C. " 12/15/1989 - "The small amount of pro-NPY found in the tumors was characterized by "in vitro conversion" with endoproteinase Lys-C. "
2.	Sudden Infant Death (SID) 08/30/2002 - "Digestion with endoproteinase Lys-C resulted in a protein fragment containing exclusively SRCR and SID domains that binds to S. "
3.	Scrapie 09/25/1990 - "Analysis of carboxy-terminal peptides derived from endoproteinase Lys-C digests of the scrapie isoform of the hamster prion protein revealed that the majority of the molecules are glycoinositol phospholipid linked through ethanolamine attached at serin-231. "
4.	Metrorrhagia (Spotting) 09/01/2007 - "The effects of the conditions were investigated separately and the optimal conditions were: heat denaturation of RNase B, chemical denaturation of HRP, RNase B digestion with endoproteinase Lys-C, HRP digestion with trypsin, 12 - 16 h of digestion, 50% acetonitrile-5% trifluoroacetic acid of the extraction solution, sandwich spotting method of the sample."
5.	Herpes Zoster 11/01/1991 - "The reactivity of 5H4 with porcine zona glycoproteins was destroyed by chymotrypsin digestion, but the antigen epitope was resistant to proteolysis by trypsin and endoproteinase Lys-C. "

Related Drugs and Biologics

1.	Trypsin
2.	Protein Isoforms (Isoforms)
3.	Ethanolamine (Colamine)
4.	Trifluoroacetic Acid (Trifluoroacetate)
5.	Solutions
6.	Proteins (Proteins, Gene)
7.	Phospholipids (Phosphatides)
8.	Peptides (Polypeptides)
9.	Glycoproteins (Glycoprotein)
10.	Chymotrypsin