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cyclic DTPA anhydride
Also Known As:
CDTPAA; DTPA cyclic anhydride; Glycine, N,N-bis(2-(2,6-dioxo-4-morpholinyl)ethyl)-
Networked:
10
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Pentetic Acid: 1751
cyclic DTPA anhydride: 10
Carboxylic Acids: 973
Acyclic Acids
Acetates: 4994
Pentetic Acid: 1751
cyclic DTPA anhydride: 10
Experts
1.
Allen, B J
: 1 article (03/2002)
2.
Rizvi, S M
: 1 article (03/2002)
3.
Shahbazi-Gahrouei, D
: 1 article (03/2002)
4.
Williams, M A
: 1 article (03/2002)
Related Diseases
1.
Neoplasms (Cancer)
08/01/1990 - "
In animals receiving 90Y-CO17-1A prepared by the cyclic DTPA anhydride technique, tumor volume was unchanged from base line at a dose of 200 microCi/25 g.
"
01/01/1984 - "
Labeling monoclonal antibodies and F(ab')2 fragments with (111In) indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts.
"
05/01/1994 - "
Indium-111-labeled A7 monoclonal antibodies using two spacer-containing chelates, succinimido-EGS-DTPA (EGS-DTPA: diester spacer) and maleimido-C10-Bz-EDTA (C10-Bz-EDTA: hydrocarbon spacer) were investigated in human LS180 colon tumor bearing nude mice and were compared with two non-spacer chelates, cyclic DTPA dianhydride (cDTPAA) and isothiocyanatobenzyl-EDTA (SCN-Bz-EDTA).
"
03/01/2002 - "
The monoclonal antibodies, 9.2.27 against human melanoma cell lines and WM53 against leukemia cell lines, were conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa) and used as tumor-specific contrast agents in magnetic resonance imaging (MRI).
"
05/01/1987 - "
B72.3, a murine monoclonal antibody (MAb) that reacts with 85% of human colon carcinomas as well as other epithelial neoplasias, was labeled with 111In using four chelating agents: 1-(p-isothiocyanatobenzyl)-DTPA (SCN-Bz-DTPA), isobutylcarboxycarbonic anhydride (MA-DTPA), cyclic anhydride (CA-DTPA), and 1-(p-isothiocyanatobenzyl)-ethylenediaminetetraacetic acid (SCN-Bz-EDTA).
"
2.
Carcinoma (Carcinomatosis)
07/01/1994 - "
A novel 111In ligand (a C-functionalised derivative of 1,4,7-triazacyclononanetriacetic acid), termed 9N3, was covalently attached to chimeric B72.3, labelled with 111In and compared with 111In-labelled chimeric B72.3 diethylenetriaminepentaacetic acid (DTPA) cyclic anhydride conjugate (cDTPA) and a C-linked derivative of DTPA (CT-DTPA) in athymic mice bearing human colon carcinoma xenografts.
"
05/01/1987 - "
B72.3, a murine monoclonal antibody (MAb) that reacts with 85% of human colon carcinomas as well as other epithelial neoplasias, was labeled with 111In using four chelating agents: 1-(p-isothiocyanatobenzyl)-DTPA (SCN-Bz-DTPA), isobutylcarboxycarbonic anhydride (MA-DTPA), cyclic anhydride (CA-DTPA), and 1-(p-isothiocyanatobenzyl)-ethylenediaminetetraacetic acid (SCN-Bz-EDTA).
"
3.
Colorectal Neoplasms (Colorectal Cancer)
01/01/1988 - "
Monoclonal antibody CO17-1A was radiolabeled with 90Y using the cyclic DTPA anhydride technique and administered intravenously to athymic nude mice bearing SW 948 human colorectal carcinomas.
"
4.
Prostatic Neoplasms (Prostate Cancer)
01/01/1989 - "
F(ab')2 fragments (at concentrations of 5-30 mg/ml) derived from monoclonal antibodies raised against human prostate specific acid phosphatase were derivatized with a bicyclic anhydride of diethylenetriaminepentaacetic acid (cDTPAA) in the molar ratios of cDTPAA/F(ab')2 of 1:1, 5:1, 10:1 or 50:1. The most optimal product, aimed at radioimaging of prostatic cancer was obtained when the antibody fragment concentration was at least 10 mg/ml and the molar ratio of cDTPAA to F(ab')2 was 5:1. cDTPAA was added dissolved in dimethylsulfoxide (DMSO).
"
5.
Melanoma (Melanoma, Malignant)
03/01/2002 - "
The monoclonal antibodies, 9.2.27 against human melanoma cell lines and WM53 against leukemia cell lines, were conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa) and used as tumor-specific contrast agents in magnetic resonance imaging (MRI).
"
Related Drugs and Biologics
1.
Monoclonal Antibodies
2.
Pentetic Acid (DTPA)
3.
Anhydrides
4.
Acids
5.
Edetic Acid (EDTA)
6.
B72.3 antibody
7.
cyclic DTPA anhydride
8.
Gadolinium DTPA (Magnevist)
9.
Proteins (Proteins, Gene)
10.
Ligands