HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

10,11-dihydro-10-hydroxycarbamazepine

main metabolite of oxcarbazepine; structure given in first source

Also Known As:

10-OH-carbazepine; 10-hydroxycarbamazepine; 10-hydroxycarbazepine; GP 47779; GP-47779

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzazepines: 4
      - Carbamazepine: 6086
        10,11-dihydro-10-hydroxycarbamazepine: 7

Experts

1.	Adín, Javier: 1 article (04/2005)
2.	Armijo, Juan A: 1 article (04/2005)
3.	Herranz, José L: 1 article (04/2005)
4.	Shushtarian, Mehrdad: 1 article (04/2005)
5.	Vega-Gil, Noelia: 1 article (04/2005)
6.	Balslev, T: 1 article (08/2001)
7.	Christensen, J: 1 article (08/2001)
8.	Dam, M: 1 article (08/2001)
9.	Heinsvig, E M: 1 article (08/2001)
10.	Poulsen, J H: 1 article (08/2001)

Related Diseases

1.	Trigeminal Neuralgia (Tic Douloureux) 01/01/1990 - "Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbazepine, in patients with trigeminal neuralgia." 01/01/1987 - "The dihydroketo and dihydromonohydroxy analogues of carbamazepine (GP 47680 and GP 47779) were tested against carbamazepine for efficacy and tolerability in 13 patients (6 male and 7 female, mean age 69 years) and 11 patients (5 male and 6 female, mean age 64 years), respectively, all of whom were suffering from trigeminal neuralgia. "
2.	Body Weight (Weight, Body) 04/01/2005 - "The influence of patient age and concomitant AEDs on the trough steady-state serum concentration of 10-hydroxycarbazepine (OHC) normalized to 1 mg/kg body weight of OXC or concentration-to-dose ratio (OHC-OXC-CDR) was assessed by analysis of covariance. " 04/01/1989 - "An overall serum therapeutic concentration range, in the six patients, of 50-110 mumol/l of 10-OH-carbazepine corresponding to a daily effective dose range of 1200-2400 mg (14.6-35.6 mg/kg body weight) oxcarbazepine, was observed. "
3.	Seizures (Absence Seizure) 12/27/1994 - "Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures."
4.	Pain (Aches) 04/01/1989 - "An excellent therapeutic response to oxcarbazepine was seen in all patients with pain control correlating well with serum drug concentrations of oxcarbazepine and its primary active metabolite 10-OH-carbazepine. "
5.	Muscle Spasticity (Spastic) 12/01/1988 - "The previously described anti-spastic effect of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine was found accidentally in 2 patients undergoing a double-blind comparative study for evaluation of antiepileptic effect. "

Related Drugs and Biologics

1.	Oxcarbazepine (Trileptal)
2.	Carbamazepine (Tegretol)
3.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Plasmapheresis