4-hydroxyifosfamide

Also Known As:

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinan-4-ol 2-oxide; 4-hydroxy-ifosfamide; 2H-1,3,2-Oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Mahteme, Haile: 1 article (01/2011)
2.	Stuart, O Anthony: 1 article (01/2011)
3.	Sugarbaker, Paul H: 1 article (01/2011)
4.	Van der Speeten, Kurt: 1 article (01/2011)
5.	Beijnen, J H: 1 article (09/2001)
6.	Keizer, H J: 1 article (09/2001)
7.	Kerbusch, T: 1 article (09/2001)
8.	Mathĵt, R A: 1 article (09/2001)
9.	Ouwerkerk, J: 1 article (09/2001)
10.	Rodenhuis, S: 1 article (09/2001)

Related Diseases

1.	Neoplasms (Cancer) 09/15/1993 - "The concentrations of IFO and of 4-hydroxyifosfamide in blood and tumors at different body temperatures (controlled by water bath immersion) were determined over 120 min and WBC counts were obtained. " 01/01/2011 - "4-Hydroxyifosfamide within peritoneal surface cancer nodules suggested a favorable pharmacologic endpoint in the study of ifosfamide administered in the operating room." 01/01/2011 - "Both ifosfamide and 4-hydroxyifosfamide could be recovered from peritoneal tumor nodules throughout the 90 minutes of ifosfamide continuous infusion and exceeded plasma concentrations. " 01/01/2011 - "The concentrations of ifosfamide and 4-hydroxyifosfamide were determined in plasma, peritoneal fluid, urine, and when possible, within small tumor nodules less than 1 cm. " 03/01/1997 - "A high-performance liquid chromatographic method has been developed for the determination of 4-hydroxyifosfamide, a metabolite of ifosfamide, in plasma of cancer patients. "
2.	Sarcoma (Soft Tissue Sarcoma) 09/01/2001 - "The population pharmacokinetics and pharmacodynamics of the cytostatic agent ifosfamide and its main metabolites 2- and 3-dechloroethylifosfamide and 4-hydroxyifosfamide were assessed in patients with soft tissue sarcoma. "
3.	Neuroblastoma 03/01/1997 - "The data from these experiments showed that neuroblastoma cells (SK-N-SH, SK-N-LO and IMR-5) were unable to activate CP and IF, but in the presence of rat liver microsomes considerable cytotoxicity was achieved, similar to those of the preactivated derivatives maphosphamide (MP) and 4-hydroxy-ifosfamide (4-OH-IF). "
4.	Breast Neoplasms (Breast Cancer) 05/01/2000 - "The antitumor activity of 4-hydroxy-ifosfamide (4-OH-IF), the active form of ifosfamide, and vinorelbine (VNB) and their interaction were investigated in two established breast cancer cell lines (MCF-7 and BRC-230) and in 10 primary breast cancer cultures. "

Related Drugs and Biologics

1.	Ifosfamide
2.	Cytostatic Agents
3.	Vinorelbine (Navelbine)
4.	maphosphamide
5.	dechloroethylcyclophosphamide
6.	chloroacetaldehyde