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arachidonyl transacylase

catalyzes CoA-independent transfer of arachidonate from phosphatidylcholine to lysoplasmenylethanolamine

Also Known As:

CoA-independent transacylase

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - arachidonyl transacylase: 3

Related Diseases

1.	Endotoxemia 01/01/1999 - "In agreement with in vitro study, our present study demonstrates that dietary high alpha-linolenate suppresses PAF production in rat kidney during systemic endotoxemia, and which is mainly due to the decrease in alkylacyl-GPC content, altered fatty acid compositions of the precursor lipids and lower CoA-independent transacylase activity."
2.	Joint Diseases (Joint Disease) 09/01/1994 - "We have compared biochemical and pharmacological characteristics of CoA-independent transacylase (CoA-IT) activity of microsomes from U937 cells to those of two other enzymes involved in arachidonate metabolism, a human type II low molecular weight (M(r) 14,000, LMW) PLA2 isolated from synovial fluid of patients with inflammatory joint disease and a high molecular weight (M(r) 85,000, HMW) PLA2 enzyme isolated from the cytosol of human monocytic U937 cells. "
3.	Hyperinsulinism (Hyperinsulinemia) 05/01/1997 - "The sustained hyperinsulinemia stimulated plasma membrane CoA-independent transacylase activity, which is responsible for the mobilization of arachidonates into lyso-PAF, to form l-alkylarchidonoyl-glycerophosphocholine. "

Related Drugs and Biologics

1.	alpha-Linolenic Acid (Linolenic Acid)
2.	Lipids
3.	Fatty Acids (Saturated Fatty Acids)
4.	Enzymes
5.	Coenzyme A (CoA)
6.	O-deacetyl platelet activating factor