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6-heptyne-2,5-diamine
RN given refers to cpd without isomeric designation
Also Known As:
6-heptyne-2,5-diamine, R-(R*,R*)-isomer; 8-methyl-8-acetylenic putrescine; MDL 72175; MDL-72175; delta-methyl-alpha acetylene putrescine; methyl-acetylenicputrescine; methylacetylenic putrescine
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Diamines: 518
6-heptyne-2,5-diamine: 3
Hydrocarbons: 1713
Acyclic Hydrocarbons
Alkynes: 217
6-heptyne-2,5-diamine: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1999 - "
Sensitivity of several human and mouse cancer cell lines to methylacetylenic putrescine (MAP) was evaluated using clonogenic, sulforhodamine B and cell counting assays.
"
11/01/1984 - "
The combination MDL 72175 plus methylglyoxal bis(guanylhydrazone) also gave additive antitumor effects on P388 leukemia, associated with an increased uptake of methylglyoxal bis(guanylhydrazone); in contrast, antagonistic effects were observed with this combination on EMT6 tumors in mice.
"
01/01/1999 - "
Effects of methylacetylenic putrescine, an ornithine decarboxylase inhibitor and potential novel anticancer agent, on human and mouse cancer cell lines.
"
11/01/1984 - "
In combination therapy, MDL 72175 plus Adriamycin gave at least additive antitumor effects on solid tumors and experimental leukemias in animals.
"
11/01/1984 - "
MDL 72175 depleted putrescine and spermidine levels in the tumors to the same extent as did alpha-difluoromethylornithine.
"
2.
Sarcoma (Soft Tissue Sarcoma)
11/01/1984 - "
In the EMT6 sarcoma, MDL 72175 achieved at low doses a greater maximal antitumor effect than did alpha-difluoromethylornithine.
"
3.
Experimental Leukemia
11/01/1984 - "
In combination therapy, MDL 72175 plus Adriamycin gave at least additive antitumor effects on solid tumors and experimental leukemias in animals.
"
4.
Leukemia P388
11/01/1984 - "
The combination MDL 72175 plus methylglyoxal bis(guanylhydrazone) also gave additive antitumor effects on P388 leukemia, associated with an increased uptake of methylglyoxal bis(guanylhydrazone); in contrast, antagonistic effects were observed with this combination on EMT6 tumors in mice.
"
5.
Experimental Arthritis
02/01/1990 - "
Methylacetylenic putrescine (MAP), an inhibitor of polyamine biosynthesis, prevents the development of collagen-induced arthritis.
"
Related Drugs and Biologics
1.
Ornithine Decarboxylase (Decarboxylase, Ornithine)
2.
Spermidine
3.
Putrescine
4.
Polyamines
5.
Mitoguazone (MGBG)
6.
Doxorubicin (Adriamycin)
7.
Antineoplastic Agents (Antineoplastics)
8.
Eflornithine (Ornidyl)
9.
lissamine rhodamine B (sulforhodamine B)
Related Therapies and Procedures
1.
Therapeutics