DAT protocol 1 (DAT I)

chemotherapy protocol consisting of above compounds; used in the treatment of acute leukemia

Also Known As:

DAT I; SAB regimen; TAD regimen; TAD9 protocol

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - DAT protocol 1: 6
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - DAT protocol 1: 6
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - DAT protocol 1: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Cytarabine: 6662
        DAT protocol 1: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Thioguanine: 835
        DAT protocol 1: 6
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Cytarabine: 6662
        DAT protocol 1: 6
  - Arabinonucleosides: 1
    - Cytarabine: 6662
      - DAT protocol 1: 6
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        DAT protocol 1: 6
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        DAT protocol 1: 6
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        DAT protocol 1: 6

Experts

1.	Airoldi, Flavio: 1 article (12/2008)
2.	Bedogni, Francesco: 1 article (12/2008)
3.	Bonizzoni, Erminio: 1 article (12/2008)
4.	Brambilla, Nedy: 1 article (12/2008)
5.	Briguori, Carlo: 1 article (12/2008)
6.	Carlino, Mauro: 1 article (12/2008)
7.	Chieffo, Alaide: 1 article (12/2008)
8.	Colombo, Antonio: 1 article (12/2008)
9.	Cosgrave, John: 1 article (12/2008)
10.	Godino, Cosmo: 1 article (12/2008)

Related Diseases

1.	Leukemia 01/01/1987 - "Between July 1, 1981, and July 1, 1985, 167 patients with acute myelogeneous leukemia (AML) were treated with one or, if necessary, two courses of a modified TAD regimen (TAD9) for induction. " 06/01/1985 - "102 patients with AML (leukemia after preleukemia, 2nd neoplasia included) were treated for remission induction by a modified TAD regimen in Munster; 55 patients (54%) achieved a complete remission (CR). "
2.	Preleukemia 06/01/1985 - "102 patients with AML (leukemia after preleukemia, 2nd neoplasia included) were treated for remission induction by a modified TAD regimen in Munster; 55 patients (54%) achieved a complete remission (CR). "
3.	Neoplasms (Cancer) 06/01/1985 - "102 patients with AML (leukemia after preleukemia, 2nd neoplasia included) were treated for remission induction by a modified TAD regimen in Munster; 55 patients (54%) achieved a complete remission (CR). "
4.	Cognitive Dysfunction 11/01/1993 - "These results suggest that in DAT: (i) significant brain atrophy is present early in the disease process, (ii) brain atrophy correlates with severity of cognitive impairment, and (iii) there is greater involvement of the telencephalic association system than whole brain, and there is relative sparing of the caudate, lenticular and thalamic nuclei."
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/01/1987 - "Ninety-seven patients less than or equal to 70 years of age with previously untreated primary acute myeloblastic leukemia were randomly treated with either the DAT or TAD regimen: daunorubicin (70 mg/m2/day) administered on Days 1-3 (DAT) or 5-7 (TAD) of a 7-day sequence consisting of cytarabine (200 mg/m2/day) and 6-thioguanine (200 mg/m2/day). "

Related Drugs and Biologics

1.	Thioguanine (Tioguanine)
2.	Lipids
3.	Daunorubicin (Cerubidine)
4.	Cytarabine (Cytosar-U)
5.	Aspirin (Acetylsalicylic Acid)
6.	Antihypertensive Agents (Antihypertensives)
7.	thienopyridine

Related Therapies and Procedures

1.	Remission Induction
2.	Drug-Eluting Stents
3.	Therapeutics