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5,9-dimethyldibenzo(c,g)carbazole

structure given in first source

Also Known As:

5,9-diMe-DBC; DiMeDBC; 7H-Dibenzo(c,g)carbazole, 5,9-dimethyl-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        5,9-dimethyldibenzo(c,g)carbazole: 4
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - 5,9-dimethyldibenzo(c,g)carbazole: 4

Experts

1.	Gábelová, Alena: 3 articles (10/2011 - 01/2002)
2.	Machala, Miroslav: 2 articles (10/2011 - 06/2009)
3.	Milcová, Alena: 2 articles (10/2011 - 06/2009)
4.	Topinka, Jan: 2 articles (10/2011 - 06/2009)
5.	Trilecová, Lenka: 2 articles (10/2011 - 06/2009)
6.	Hrubá, Eva: 1 article (10/2011)
7.	Krčmár, Pavel: 1 article (10/2011)
8.	Marvanová, Soňa: 1 article (10/2011)
9.	Mesárošová, Monika: 1 article (10/2011)
10.	Schmuczerová, Jana: 1 article (10/2011)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2009 - "Our recent study showed that the liver carcinogens 7H-dibenzo[c,g]carbazole (DBC) and 5,9-dimethyldibenzo[c,g]carbazole (DiMeDBC), but not the sarcomagen N-methyldibenzo[c,g]carbazole (N-MeDBC), induced several cellular events associated with tumor promotion in WB-F344 cells, an in vitro model of liver oval cells [J. "
2.	Hepatocellular Carcinoma (Hepatoma) 10/01/2011 - "Our data clearly demonstrated differences in the mechanisms involved in the biological activity of DiMeDBC and N-MeDBC in human hepatoma cells; the genotoxicity of these DBC derivatives is closely related to CYP1A1/2 expression." 10/01/2011 - "The goal of this study was to investigate the genotoxicity of 7H-dibenzo[c,g]carbazole (DBC), a ubiquitous environmental pollutant, and its methyl derivatives, 5,9-dimethylDBC (DiMeDBC), a strict hepatocarcinogen, and N-methylDBC (N-MeDBC), a specific sarcomagen in human hepatoma HepG2 cells, and to infer potential mechanisms underlying the biological activity of particular carcinogen. " 10/01/2011 - "A significant increase in DNA strand breaks following incubation of exposed cells with a repair-specific endonuclease (Fpg protein) suggested that either oxidative DNA damage or unstable DNA-adducts might underlie DiMeDBC genotoxicity in human hepatoma cells. "
3.	Carcinogenesis 10/23/1998 - "To see whether the characteristics of susceptibility or resistance to tumorigenesis were also expressed in the liver and lung, the two lines were submitted comparatively to treatment with 5,9-dimethyl dibenzo[c,g]carbazole (DiMeDBC), a potent hepatocarcinogenic derivative of the ubiquitous heterocyclic carcinogenic pollutant, 7H-dibenzo[c,g]-carbazole (DBC). "
4.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/2002 - "Occasionally, B[a]P induced chromosomal aberrations and micronuclei, and diMeDBC induced micronuclei, but not chromosomal aberrations. " 01/01/2002 - "After B[a]P treatment, we found a reduction in DNA breaks and chromosomal aberrations; after treatment with diMeDBC, we observed a reduction in DNA breaks. "

Related Drugs and Biologics

1.	carbazole
2.	Carcinogens
3.	N-methyl-7H-dibenzo(c,g)carbazole
4.	Environmental Pollutants (Pollutants, Environmental)
5.	Cytochrome P-450 CYP1A1 (CYP1A1)
6.	DNA Adducts
7.	Proteins (Proteins, Gene)
8.	Endonucleases
9.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)