platelet activating factor receptor

11/01/1994 - "However, the efficacy of platelet-activating factor receptor antagonist was significantly greater in patients with Gram-negative sepsis (test for interaction, p = .03). "
12/01/1998 - "Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. "
02/26/2013 - "Finally, as PAR1 seems to play a singular role in Streptococcus pneumoniae-induced sepsis through a crosstalk between PAR1 and platelet-activating factor receptor, the exact role of PAR1 needs to be investigated in other models of sepsis. "
11/01/1994 - "No differences in mortality rates were found between the placebo and the platelet-activating factor receptor antagonist groups in the absence of Gram-negative sepsis. "
11/01/1994 - "When the Gram-negative sepsis population was stratified by age and these five prognostic factors were controlled for, the relative risk of death of the platelet-activating factor receptor antagonist group was 0.61 (0.34 to 1.08, 95% confidence interval; p = .09). "

01/01/2020 - "Platelet activating factor receptor acts to limit colitis-induced liver inflammation."
01/01/2020 - "Here, we examined the role of platelet activating factor receptor (PAFR) in colitis-associated liver damage using dextran sulfate sodium (DSS) and anti-CD40-induced colitis models. "
06/01/1996 - "Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis."
01/01/2019 - "Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome."
01/01/2003 - "To directly assess the impact of platelet-activating factor on the development of colitis, we also determined the efficacy of a specific platelet-activating factor receptor antagonist for preventing dextran sulfate sodium-induced colitis. "

03/01/2012 - "This suggests that the platelet activating factor receptor (PAFR) acts to suppress chronic inflammation in response to other stimuli, such as barrier disruption. "
01/01/1999 - "We hypothesized that the activation of PAF receptors is central to the development of inflammation and epithelial injury induced by acute O3 exposure in mice. "
09/14/2023 - "Provided herein are novel cyclopentathiophene carboxamide derivatives as platelet activating factor receptor (PAFR) antagonists, pharmaceutical compositions, use of such compounds in treating ocular diseases, allergies, and inflammation-related diseases, and processes for preparing such compounds."
06/08/2023 - "Provided herein are cyclopentathiophene carboxamide derivatives as platelet activating factor receptor (PAFR) antagonists, pharmaceutical compositions, use of such compounds in treating ocular diseases, allergies, and inflammation-related disorders, and processes for preparing such compounds."
01/01/2020 - "Platelet activating factor receptor acts to limit colitis-induced liver inflammation."

12/01/2010 - "Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells."
02/15/2010 - "A screen of relevant pathway inhibitors identified a prominent role for the platelet-activating factor receptor (PAFr) in hypoxia-associated bacterial translocation, wherein pharmacologic antagonists of PAFr blocked bacterial translocation by as much as 80 +/- 6%. "
02/15/2010 - "Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia."
08/01/2004 - "Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice."
07/12/2004 - "Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia."

02/15/2004 - "Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice."
02/01/2014 - "Prevotella intermedia induces severe bacteremic pneumococcal pneumonia in mice with upregulated platelet-activating factor receptor expression."
01/01/2006 - "pneumoniae utilizes the platelet-activating factor receptor (PAFR) to invade the respiratory epithelium and that the PAFR is upregulated during viral infection, we here used PAFR gene-deficient (PAFR-/-) mice to determine the role of this receptor during postinfluenza pneumococcal pneumonia. "
06/05/2012 - "CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner."