S-pentachlorobuta-1,3-dien-yl-cysteine (PCBC)

nephrotoxic; structure given in first source

Also Known As:

PCBC; 5-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine; S-pentachlorobutadienyl-L-cysteine; L-Cysteine, S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Dongjie: 1 article (01/2022)
2.	Gao, Wenzhe: 1 article (01/2022)
3.	Li, Zheng: 1 article (01/2022)
4.	Liu, Jixing: 1 article (01/2022)
5.	Xiao, Tijun: 1 article (01/2022)
6.	Yu, Xiao: 1 article (01/2022)
7.	Zang, Longjun: 1 article (01/2022)
8.	Zhang, Xianlin: 1 article (01/2022)
9.	Zhu, Hongwei: 1 article (01/2022)
10.	Bao, Kai-Hu: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/22/2021 - "This study was designed as a means of comparing the clinical efficacy and long-term outcomes of covered vs bare stent insertion as a treatment for distal malignant biliary obstruction (DMBO) caused by primary common biliary cancer (PCBC).This retrospective study was designed using data collected between January 2012 and December 2019 to assess the short- and long-term outcomes in patients with DMBO caused by PCBC treated by inserting either bare or covered stents were compared.Ninety" 01/01/2022 - "Based on RNA-seq datasets from The Cancer Genome Atlas (TCGA) and Progenitor Cell Biology Consortium (PCBC), one-class logistic regression (OCLR) algorithm was applied to compute the stemness index (mRNAsi) of HCC patients. " 07/14/2023 - "Based on RNA-seq data from The Cancer Genome Atlas (TCGA), Gene-Expression Omnibus (GEO) and Progenitor Cell Biology Consortium (PCBC), mRNA expression-based stemness index (mRNAsi) was calculated by one-class logistic regression (OCLR) algorithm. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/1991 - "These results show that PCBC-induced mitochondrial dysfunction occurred as a result of mitochondrial bioactivation and that the mitochondrion is the critical subcellular target in PCBC toxicity. " 09/30/1987 - "These results suggest that PCBC-induced mitochondrial dysfunction may initiate the renal proximal tubule injury." 01/01/1991 - "Pentachlorobutadienyl-L-cysteine (PCBC) toxicity: the importance of mitochondrial dysfunction."
3.	AIDS-Related Lymphoma (Lymphoma, AIDS Related) 02/01/1998 - "Primary body cavity based (PCBC) AIDS-related lymphoma is a relatively newly described disease entity with morphologic features bridging ALCL and large cell immunoblastic lymphoma with a CD30+ null immunophenotype. "
4.	Immunoblastic Large-Cell Lymphoma (Lymphoma, Large Cell, Immunoblastic) 02/01/1998 - "Primary body cavity based (PCBC) AIDS-related lymphoma is a relatively newly described disease entity with morphologic features bridging ALCL and large cell immunoblastic lymphoma with a CD30+ null immunophenotype. "
5.	Necrosis 01/01/1988 - "At 0.1 mm-PCBC the increase in biochemical parameters of nephrotoxicity was accompanied by massive tubular necrosis. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Messenger RNA (mRNA)
3.	Cysteine (L-Cysteine)
4.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Stents
2.	Phototherapy (Light Therapy)
3.	Drug Therapy (Chemotherapy)