calpain inhibitors

05/01/2000 - "Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves."
04/01/2007 - "The calpain inhibitor prevented necrotic morphology induced by hypoxia and converted partially to apoptotic morphology with nuclear segmentation. "
11/05/1990 - "Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices."
04/23/1993 - "Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo."
09/19/1997 - "The calpain inhibitor, MDL28170, significantly improved the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization. "

01/14/2013 - "The data reported here, using this model, demonstrated the potential of the macrocyclic calpain inhibitor, CAT811, to act as a therapeutic for treatment of cortical cataract."
01/14/2013 - "We used sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the medical treatment of human cataract. "
01/14/2013 - "A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model."
12/01/2008 - "Evaluation of a novel calpain inhibitor as a treatment for cataract."
06/01/2004 - "Calpain inhibitors show the potential to serve as non-surgical alternatives in treating diabetic cataract and other types of these disorders. "

01/01/2015 - "Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury."
03/01/2005 - "Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats."
10/01/2008 - "Therapeutic efficacy of SJA6017, a calpain inhibitor, in rat spinal cord injury."
06/01/2009 - "In this study, we evaluated the effect of a calpain inhibitor, AK 295, on spinal cord structure, neurologic function, and apoptosis after spinal cord injury (SCI) in a murine model. "
12/01/2007 - "Although calpain inhibition has previously been demonstrated to be neuroprotective following spinal cord injury, most studies administered the calpain inhibitor at a single time point. "

02/20/1999 - "We examined effects of a calpain inhibitor on delayed neuronal death after transient forebrain ischemia. "
10/01/1995 - "IGFs and calpain inhibitors had no effect on necrotic death during ischemia, but they significantly reduced apoptotic death during reperfusion. "
07/01/1994 - "Experiments were conducted to determine whether a potent, reversible calpain inhibitor could reduce the cortical ischemic brain damage associated with focal ischemia in the rat. "
03/01/1994 - "The proteolytic response to postdecapitation ischemia was also reduced by the calpain inhibitor. "
03/01/1994 - "A final group of 12 animals was decapitated after injection of vehicle or calpain inhibitor, and the proteolytic response was measured after 60 minutes of total ischemia. "

02/20/1999 - "Our data also show a palliative effect of the calpain inhibitor on the neurotoxic damage, which offers a new and potent treatment of transient forebrain cerebral ischemia."
03/01/1994 - "Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia."
11/01/2001 - "Recently, calpain inhibitors have been shown to provide benefit in rat models of focal head injury and focal cerebral ischemia. "
01/01/1998 - "The efficacy of a potent, central nervous system-penetrating calpain inhibitor (MDL 28,170) was evaluated in a temporary model of focal cerebral ischemia to determine the window of opportunity for intracellular protease inhibition. "
01/01/2008 - "Calpain inhibitors showed neuroprotective effects in adult rat cerebral ischemia models. "