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benalfocin
RN & RR given from first source; RN not in Chemline 9/28/83; structure given in first source
Also Known As:
6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine; SK&F 86466; SK&F-86466; SKF 86466; benalfocin hydrochloride
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzazepines: 5
benalfocin: 4
Related Diseases
1.
Hypertension (High Blood Pressure)
01/01/1986 - "
SK&F 86466 was even less effective in the two-kidney one-clip Goldblatt model in which hypertension is maintained by the renin-angiotensin system rather than by the sympathetic nervous system.(ABSTRACT TRUNCATED AT 250 WORDS)
"
2.
Respiratory Insufficiency (Respiratory Failure)
01/01/1991 - "
The present study was performed in order to evaluate the effects of the selective alpha 2-adrenoceptor antagonist 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SK&F 86466) on dermorphin-induced analgesia, respiratory depression and inhibition of locomotor activity in the conscious rat.
"
3.
Tachycardia (Tachyarrhythmias)
01/01/1986 - "
Oral administration of SK&F 86466 was associated with tachycardia, which reached maximal levels within 15 min after dosing, followed by an interval of bradycardia.
"
01/01/1986 - "
In contrast, heart rate was still significantly elevated by phentolamine 90 min postdosing, whereas the transient tachycardia induced by SK&F 86466 had dissipated within 30 min. SK&F 86466 was also an effective antihypertensive agent in the spontaneously hypertensive rat, although lower antihypertensive efficacy was observed than in the DOCA-salt model.
"
4.
Bradycardia
01/01/1986 - "
Oral administration of SK&F 86466 was associated with tachycardia, which reached maximal levels within 15 min after dosing, followed by an interval of bradycardia.
"
5.
Cardiac Arrhythmias (Arrythmia)
07/12/1995 - "
Efaroxan, idazoxan, or SKF 86466 alone reduced the threshold dose of ouabain necessary to induce cardiac arrhythmia as a sign for arrhythmogenic effects.
"
Related Drugs and Biologics
1.
benalfocin
2.
dermorphin
3.
Desoxycorticosterone Acetate (DOCA)
4.
Idazoxan
5.
Salts
6.
Phentolamine (Z-Max)
7.
Ouabain (G Strophanthin)
8.
Antihypertensive Agents (Antihypertensives)
9.
efaroxan
10.
2-methoxyidazoxan
Related Therapies and Procedures
1.
Surgical Instruments (Clip)
2.
Analgesia
3.
Oral Administration