fucosyl GM1 ganglioside

Also Known As:

Fuc-GM1 antigen; Fucalpha1-2Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-1'Cer; IV(2)-Fuc alpha,II(3)-NeuAc alpha-Gg4Cer; fucosyl GM1; fucosyl-GM1 antigen; fucosyl-GM1a; ganglioside antigen Fuc-GM1

Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Brezicka, T: 2 articles (10/2005 - 03/2001)
2.	Ragupathi, Govind: 2 articles (01/2005 - 09/2004)
3.	Chen, Xi: 1 article (01/2018)
4.	Ghosh, Tamashree: 1 article (01/2018)
5.	Li, Yanhong: 1 article (01/2018)
6.	McArthur, John B: 1 article (01/2018)
7.	Santra, Abhishek: 1 article (01/2018)
8.	Wang, Peng G: 1 article (01/2018)
9.	Yang, Xiaoxiao: 1 article (01/2018)
10.	Yu, Hai: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2004 - "Vaccination with the synthetic fucosyl GM1-KLH conjugate induces an IgM antibody response against fucosyl GM1 and tumor cells expressing fucosyl GM1, comparable with the response induced by the bovine derivative. " 12/02/1991 - "Tumor-cell killing by MAbs against fucosyl GM1, a ganglioside antigen associated with small-cell lung carcinoma." 12/02/1991 - "Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in vivo. " 01/01/2018 - "A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. " 01/01/2005 - "This approach alone induced strong antibody responses against the glycolipids GM2, fucosyl GM1 and globo H and the mucin backbone MUC1, and cancer cells expressing these antigens. "
2.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/01/2006 - "Fucosyl GM1 has been reported to be specifically expressed in small cell lung cancer (SCLC) cells. " 10/01/2006 - "Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines." 12/02/1991 - "Tumor-cell killing by MAbs against fucosyl GM1, a ganglioside antigen associated with small-cell lung carcinoma." 10/01/2005 - "Glycolipids GM2, GD2, GD3, fucosyl GM1, sialyl Lewis a (sLe(a)) and globo H, and polysialic acid on embryonal NCAM, are cell-surface antigens expressed on small cell lung cancer (SCLC) biopsy specimens. " 01/01/1992 - "With the aid of specific monoclonal antibodies, tumor tissues from 68 patients with lung cancer were examined for their expression of two small cell lung carcinoma (SCLC) antigens, Fuc-GM1 (fucosyl GM1; IV2FucII3NeuAc GgOse4) and neural-cell adhesion molecule (NCAM), and two broader tumor antigens, carcinoembryonic antigen (CEA) and carbohydrate cancer-associated antigen CA 50. "
3.	Lung Neoplasms (Lung Cancer) 09/26/1997 - "9-O-acetyl-GD3 was detected only on melanoma while fucosyl GM1 was detected only on small cell lung cancers (SCLC). " 10/01/2005 - "Selection of GM2, fucosyl GM1, globo H and polysialic acid as targets on small cell lung cancers for antibody mediated immunotherapy." 01/01/1992 - "Coexpression of ganglioside antigen Fuc-GM1, neural-cell adhesion molecule, carcinoembryonic antigen, and carbohydrate tumor-associated antigen CA 50 in lung cancer." 01/01/1992 - "With the aid of specific monoclonal antibodies, tumor tissues from 68 patients with lung cancer were examined for their expression of two small cell lung carcinoma (SCLC) antigens, Fuc-GM1 (fucosyl GM1; IV2FucII3NeuAc GgOse4) and neural-cell adhesion molecule (NCAM), and two broader tumor antigens, carcinoembryonic antigen (CEA) and carbohydrate cancer-associated antigen CA 50. "
4.	Hepatocellular Carcinoma (Hepatoma) 03/17/1986 - "Differential expression of fucosyl GM1 and a disialoganglioside with a NeuAc alpha 2-6GalNAc linkage (GD1e) in various rat ascites hepatoma cells." 02/01/1993 - "The gangliosides of the hepatoma were characterized by the appearance of the newly synthesized gangliosides, fucosyl-GM1 and alpha-galactosyl alpha-fucosyl GM1 (BGM1). " 03/17/1986 - "Yoshida sarcoma and ascites hepatomas, AH13, AH66F and AH66, but not the other 9 tumor cell lines investigated, specifically contained a disialoganglioside, NeuAc alpha 2-3Gal beta 1-3(NeuAc alpha 2-6)GalNAc beta 1-4Gal beta 1-4Glc beta 1-1ceramide (GD1e), whereas the 9 ascites hepatoma cells without GD1e contained fucosyl GM1. " 03/17/1986 - "A distinct difference in ganglioside composition among various rat ascites hepatomas and Yoshida sarcoma was observed on TLC-immunostaining with anti-fucosyl GM1 antibody, and chemical and enzymatic analyses. " 03/01/2001 - "Doxorubicin, cisplatinum and etoposide were tested in combination with human complement and a murine monoclonal antibody (MAb F12) directed against the tumor-associated ganglioside antigen fucosyl GM1 on a rat hepatoma (H4-II-E) cell line which was used as tumor model. "
5.	Autoimmune Diseases of the Nervous System 09/01/1997 - "We examined serum antibodies to 4 species of fucogangliosides: fucosyl-GM1, fucosyl-GD1b, alpha galactosyl (alpha fucosyl) GM1 and alpha galactosyl (alpha fucosyl) GD1b, in 329 patients with various neurologic diseases, 32 patients with non-neurologic autoimmune diseases and 50 healthy persons. "

Related Drugs and Biologics

1.	Gangliosides
2.	Antigens
3.	Monoclonal Antibodies
4.	Globo-H
5.	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
6.	CA-19-9 Antigen (CA 19-9 Antigen)
7.	Mucins
8.	Glycosphingolipids
9.	Glycolipids
10.	Complement System Proteins (Complement)

Related Therapies and Procedures

1.	Immunotherapy