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selenazofurin
selenazole analog of tiazofurin
Also Known As:
2 beta-ribofuranosylselenazole-4-carboxamide; 2-beta-D-ribofuranosyl-4-selenazolecarboxamide; 2-ribofuranosylselenazole-4-carboxamide
Networked:
12
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Ribonucleosides: 49
Ribavirin: 8673
selenazofurin: 12
Organic Chemicals: 133
Organoselenium Compounds: 63
selenazofurin: 12
Experts
1.
Gharehbaghi, Kamran
: 1 article (04/2002)
2.
Grünberger, Werner
: 1 article (04/2002)
3.
Jayaram, Hiremagalur N
: 1 article (04/2002)
Related Diseases
1.
Lymphoma (Lymphomas)
04/01/1985 - "
Treatment with tiazofurin, selenazofurin, or mycophenolic acid decreased guanylate pools and caused an accumulation of IMP in WIL2 human lymphoma cells.
"
11/01/1985 - "
Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture.
"
05/23/1997 - "
Selenophenfurin proved to be antiproliferative against a number of leukemia, lymphoma, and solid tumor cell lines at concentrations similar to those of selenazofurin but was more potent than the thiophene and thiazole analogues thiophenfurin and tiazofurin.
"
2.
Leukemia
04/01/1985 - "
2-beta-D-Ribofuranosyl-4-selenazolecarboxamide (selenazofurin, CI-935), the selenium analog of tiazofurin (CI-909), was 3- to 10-fold more cytotoxic to murine or human tumor cells in vitro than tiazofurin and was also more active against P388 mouse leukemia in vivo.
"
05/23/1997 - "
Selenophenfurin proved to be antiproliferative against a number of leukemia, lymphoma, and solid tumor cell lines at concentrations similar to those of selenazofurin but was more potent than the thiophene and thiazole analogues thiophenfurin and tiazofurin.
"
05/01/1986 - "
The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
"
3.
Human Influenza (Influenza)
09/01/1985 - "
In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4).
"
09/01/1985 - "
Activity of selenazofurin against influenza A and B viruses in vitro.
"
10/01/1986 - "
Effect of selenazofurin on influenza A and B virus infections of mice.
"
01/01/1986 - "
The inhibition of replication of either influenza A or B virus was additive for any combination of ribavirin and selenazofurin.
"
01/01/1986 - "
Selenazofurin inhibited growth of influenza A and B viruses at concentrations (50% inhibitory dose = 25 and 19 microM, respectively) which were similar to those at which growth was inhibited by ribavirin (50% inhibitory dose = 50 and 30 microM, respectively).
"
4.
Infections
10/01/1986 - "
Body temperature, which usually declined during infection, increased to near-normal levels in animals treated with selenazofurin, especially in animals treated a single time or for 3 days with high dose levels.
"
01/01/1993 - "
Intraperitoneal selenazofurin (1-100 mg/kg per day for 10 days) and ampligen (0.5 and 5 mg/kg every other day for 5 injections) treatments provided neither protection from the lethal infection nor increased mean survival times.
"
01/01/1993 - "
Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen.
"
10/01/1994 - "
Of these, ribavirin, ribamidine, ribavirin 2',3',5'-triacetate, tiazofurin, tiazofurin-5'-monophosphate, tiazofurin-2',3',5'-triacetate, selenazofurin, pyrazofurin, 3-deazaguanine, and 3-deazaguanosine were considered significantly inhibitory, acting against the infection by a direct antiviral (non-immunomodulatory) fashion.
"
5.
Neoplasms (Cancer)
04/01/2002 - "
BR has demonstrated potent cytotoxic activity in a diverse group of human tumor cells, specifically more active in sarcomas and CNS neoplasms compared to tiazofurin or selenazofurin.
"
04/01/1985 - "
2-beta-D-Ribofuranosyl-4-selenazolecarboxamide (selenazofurin, CI-935), the selenium analog of tiazofurin (CI-909), was 3- to 10-fold more cytotoxic to murine or human tumor cells in vitro than tiazofurin and was also more active against P388 mouse leukemia in vivo.
"
Related Drugs and Biologics
1.
tiazofurin
2.
Ribavirin (Virazole)
3.
Selenium
4.
Nucleosides
5.
Mycophenolic Acid (Cellcept)
6.
Antiviral Agents (Antivirals)
7.
taribavirin (viramidine)
8.
Thiophenes
9.
Thiazoles
10.
Phosphatidylinositols (Phosphatidylinositol)
Related Therapies and Procedures
1.
Therapeutics
2.
Injections