clerocidin

Also Known As:

Antibiotic PR 1350; PR 1350; PR 1381; PR 1383; PR-1350; 1-Naphthalenecarboxaldehyde, 5,5'-((tetrahydro-3'a,7'a-dihydroxydispiro(oxirane-2,3'(2'H)-difuro(2,3-b:2',3'-e)(1,4)dioxin-7'(6'H),2''-oxirane)-2',6'-diyl)bis(methylene))bis(3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethyl)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - clerocidin: 2

Experts

1.	Menegazzo, Ileana: 1 article (03/2009)
2.	Moro, Stefano: 1 article (03/2009)
3.	Nadai, Matteo: 1 article (03/2009)
4.	Palumbo, Manlio: 1 article (03/2009)
5.	Richter, Sara N: 1 article (03/2009)
6.	Capranico, G: 1 article (10/2001)
7.	Gatto, B: 1 article (10/2001)
8.	Moro, S: 1 article (10/2001)
9.	Palumbo, M: 1 article (10/2001)
10.	Richter, S: 1 article (10/2001)

Related Diseases

Poisoning

03/07/2009 - "Clerocidin is a complex natural molecule which induces DNA damage both directly and through irreversible/reversible poisoning of prokaryotic/eukaryotic topoisomerases II. By analysis of clerocidin reactivity towards adenine and thymine bases, we were able to fully characterize and compare the unique direct reactivity of clerocidin towards the four DNA bases, both in solution and in the DNA context. "
10/15/2001 - "The guanine-alkylating ability of clerocidin suggests an unprecedented mechanism of topo II poisoning, according to which the enzyme renders the drug reactive toward DNA by distorting the double-helical structure of the nucleic acid at the cleavage site."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Thymine
3.	Solutions
4.	Nucleic Acids
5.	Guanine
6.	Enzymes
7.	Adenine
8.	trioctyl phosphine oxide (TOPO)