1,3-dimethylthiourea

11/09/1999 - "Both ischemia/reperfusion and PC caused nuclear translocation and activation of NFkappaB, which was blocked by both DMTU and SN50. "
09/01/1995 - "Treatment with the nonspecific scavenger DMTU (n = 10) significantly diminished the increase in discharge activity evoked by ischemia and reperfusion. "
06/01/1993 - "In an additional 13 ischemia-sensitive C fibers, DMTU significantly (p < 0.05) attenuated ischemia-induced increases in discharge frequency from 0.42 +/- 0.18 to 0.24 +/- 0.1 impulses per second (ischemia versus DMTU + ischemia, respectively). "
05/01/1993 - "Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats."
12/01/1992 - "Dimethylthiourea treatment altered the clinical outcome after ischemia. "

09/01/2003 - "Dimethylthiourea produced a significant protection against cisplatin-induced acute renal failure, and the effect was associated with an inhibition of apoptosis. "
01/01/2008 - "Besides not presenting any direct effect on mitochondria, DMTU substantially inhibited cisplatin-induced mitochondrial injury and cellular death by apoptosis, suppressing the occurrence of acute renal failure. "
01/15/2009 - "Dimethylthiourea (DMTU), a potent hydroxyl radical scavenger, affords protection against cisplatin (CDDP)-induced acute renal failure (ARF). "
02/01/1998 - "Hydroxyl radical scavengers, dimethyl sulfoxide, mannitol and benzoic acid, significantly reduced cisplatin-induced cytotoxicity and, treatment with dimethyl sulfoxide or dimethylthiourea provided significant protection against cisplatin-induced acute renal failure. "

01/01/1992 - "After 7 days of DMTU, a significant reduction in proteinuria occurred as compared to AN controls (62.4 +/- 13.3 vs. 155.0 +/- 24.0 mg/24 h). "
12/01/2006 - "The PA-treated animals developed worse proteinuria and histopathologic disease and exhibited more DNA damage than the DMTU pretreated group. "
11/01/1991 - "DMTU administration to rats with AN caused a significant (p less than 0.01) reduction in their proteinuria after 7 days (52.84 +/- 13.21 mg/24 hours) when they were compared with ADR controls (155.81 +/- 20.16 mg/24 hours). "
03/01/1991 - "DMTU group (n = 12) showed significantly less proteinuria (0.6 +/- 0.1 mg/day, p less than 0.05) than control. "
10/01/1988 - "In a second series of experiments, DMTU and DFO (administered as described above and then for two additional days after the PAN) provided marked protection even when they were stopped prior to the onset of proteinuria. "

11/01/1988 - "Dimethylthiourea does not ameliorate reperfusion lung injury in dogs or rabbits."
12/01/1987 - "In contrast, though the number of H2O2-generated granulocyte was not decreased in lung lavages of DMTU-treated rabbits, treatment with DMTU could afford protection from lung injury. "
02/01/1985 - "Pretreatment with DMTU eliminated the increased CA but had no effect on the initial leukopenia or the lung injury. "
04/01/2010 - "The possible mechanisms of the protective effect of DMTU in I/R-induced lung injury may relate to the permeability of the agent allowing it to scavenge intracellular hydroxyl radicals. "
01/01/1992 - "Although DMTU was shown to block the permeability lung damage caused by phorbol myristate acetate (a neutrophil activator), this agent did not exert any effect on the CC-induced pressor response and lung injury. "

09/01/1989 - "The capacity of DMTU to scavenge MPO products may explain some of its protective effects in acute lung injury."
04/01/2010 - "DMTU pretreatment significantly attenuated the acute lung injury. "
12/01/1985 - "Dimethylthiourea consumption reflects H2O2 concentrations and severity of acute lung injury."
06/01/1992 - "Dimethylthiourea ameliorates acute lung injury induced by phorbol myristate acetate in dogs."
06/01/1992 - "The present study was designed to determine whether dimethylthiourea can ameliorate the acute lung injury produced in dogs by phorbol myristate acetate. "