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sfericase

serine protease from Bacillus sphaericus, has 2 undializable calcium ions

Also Known As:

AL-794

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        sfericase: 6
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        sfericase: 6

Experts

1.	Boyce, Malcolm: 2 articles (01/2019 - 01/2018)
2.	Chanda, Sushmita: 2 articles (01/2019 - 01/2018)
3.	Fry, John: 2 articles (01/2019 - 01/2018)
4.	Gupta, Kusum: 2 articles (01/2019 - 01/2018)
5.	Kakuda, Thomas N: 2 articles (01/2019 - 01/2018)
6.	Mitchell, Toni: 2 articles (01/2019 - 01/2018)
7.	Rito, Jennifer: 2 articles (01/2019 - 01/2018)
8.	Symons, Julian A: 2 articles (01/2019 - 01/2018)
9.	Van Remoortere, Pieter: 2 articles (01/2019 - 01/2018)
10.	Yogaratnam, Jeysen: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Sinusitis 09/01/1983 - "Sfericase has been proven effective in some chronic inflammations, such as chronic sinusitis and difficult expectoration associated with bronchopulmonary diseases. " 01/14/1994 - "Sfericase significantly reduces viscosity of human pathological bronchial secretions and has recently shown good clinical effects in treatment of bronchitis, pneumonia and sinusitis. " 02/01/1984 - "Forty patients with chronic sinusitis were treated orally with sfericase tablets (each tablet = 10,000 units), a proteolytic enzyme preparation, at a daily dosage of six tablets for adults and three tablets for children in three divided doses after each main meal for 4 weeks. "
2.	Inflammation (Inflammations) 09/01/1983 - "Sfericase inhibits various experimental acute inflammations and reduces viscosity of sputum obtained from subacute bronchitic rabbits by oral treatment. " 09/01/1983 - "Sfericase has been proven effective in some chronic inflammations, such as chronic sinusitis and difficult expectoration associated with bronchopulmonary diseases. "
3.	Human Influenza (Influenza) 01/01/2018 - "Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults." 01/01/2019 - "Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study." 01/01/2018 - "This double-blind, first-in-human Phase I study evaluated pharmacokinetics, safety and tolerability of AL-794 (prodrug of ALS-033719), a potent endonuclease inhibitor of influenza A and B in healthy volunteers. "
4.	Infections 01/01/2019 - "In a phase 1, double-blinded, randomized, placebo-controlled study, healthy subjects were inoculated intranasally with influenza virus (A/Perth/16/2009 H3N2) after confirmation of infection or on day 4. Subjects received 50 mg of AL-794, 150 mg of AL-794, or placebo twice daily for 5 days. "
5.	Chronic Bronchitis 01/01/1984 - "Clinical effects of proteinase, sfericase (AI-794), on chronic bronchitis and similar diseases."

Related Drugs and Biologics

1.	Endonucleases
2.	Prodrugs
3.	Antiviral Agents (Antivirals)
4.	Peptide Hydrolases (Proteases)
5.	Tablets