amorolfine

RN given refers to parent cpd

Also Known As:

Loceryl; Locetar; Locéryl; Odenil; Ro 14-4767-002; Ro-14-4767-002; amorolfin hydrochloride; amorolfine hydrochloride; morpholine, 4-(3-(4-(1,1-dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethyl-, cis-, (+/-)-

Networked: 117 relevant articles (27 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - amorolfine: 117

Experts

1.	Sigurgeirsson, B: 5 articles (05/2016 - 09/2003)
2.	Gupta, Aditya K: 5 articles (12/2014 - 01/2003)
3.	Baran, R: 5 articles (07/2007 - 06/2000)
4.	Sidou, F: 4 articles (05/2016 - 01/2004)
5.	Tatsumi, Yoshiyuki: 4 articles (01/2016 - 12/2002)
6.	Bunyaratavej, Sumanas: 3 articles (02/2022 - 08/2016)
7.	Leeyaphan, Charussri: 3 articles (02/2022 - 08/2016)
8.	Sarkany, Marlis: 3 articles (12/2017 - 03/2016)
9.	Schaller, Martin: 3 articles (12/2017 - 11/2009)
10.	Kerrouche, N: 3 articles (05/2016 - 07/2007)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 05/01/2017 - "According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. " 11/01/2014 - "Case of infantile onychomycosis successfully cured by 5% amorolfine nail lacquer." 05/01/2016 - "As onychomycosis is unsightly, this study clinically evaluated whether the antifungal efficacy of amorolfine 5% nail lacquer (NL) was affected by a masking, natural-coloured, cosmetic nail varnish applied 24 h later; in vitro investigations were also performed. " 05/01/2016 - "Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomised active-controlled study and in vitro assays." 08/01/2016 - "Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis."
2.	Infections 08/01/2016 - "Amorolfine nail lacquer was mentioned as an effective treatment for non-dermatophyte nail infection. " 01/01/1995 - "Within this clinical setting, amorolfine should be reserved for patients with mild infection without nail matrix involvement. " 09/01/1992 - "Last, but not least, amorolfine has an in-vitro spectrum of activity which covers some of the less common cutaneous pathogens, and hence it may prove of benefit in those infections for which treatment at present is limited." 10/01/2015 - "Sporicidal effect of amorolfine and other antimycotics used in the therapy of fungal nail infections." 08/01/2021 - "As such, there is an urgent need to design novel antifungal treatments for infections caused by Fusarium spp. Herein, 15 clinical isolates, including 5 Fusarium oxysporum and 10 Fusarium solani strains, were analyzed to explore the relative inhibitory effects of different combinations of amorolfine (AMO) and voriconazole (VOR) on the growth of these fungal pathogens. "
3.	Tinea (Ringworm) 01/01/1993 - "Combination of amorolfine with various antifungal drugs in dermatophytosis." 09/01/1991 - "[Retention of amorolfine in the skin tissue as measured by prevention of the development of experimental dermatophytosis in guinea pigs]." 01/01/1992 - "In models of superficial fungal infection--trichophytosis and vaginal candidosis--amorolfine has a high activity. " 11/01/2011 - "Amorolfine 0.25% cream is found to be safe and effective, like clotrimazole, when used topically in tinea corporis." 05/01/2019 - "A randomized, double-blind trial of amorolfine 0.25% cream and sertaconazole 2% cream in limited dermatophytosis."
4.	Dermatomycoses 09/01/1992 - "A once-daily application of amorolfine cream can be recommended for the treatment of dermatomycoses on the basis of the results from this study. " 09/01/1992 - "Dose-finding study of amorolfine cream (0.125%, 0.25% and 0.5%) in the treatment of dermatomycoses." 10/01/2004 - "The antifungal susceptibility of isolates from Chinese dermatomycosis patients to amorolfine was investigated following National Committee for Clinical Laboratory Standards (NCCLS) protocols. " 10/01/2004 - "In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China." 01/01/1995 - "Overall cure and improvement was observed in approximately 85 to 90% of patients with superficial dermatomycoses following treatment with amorolfine 0.25% cream for up to 6 weeks. "
5.	Denture Stomatitis 01/01/2005 - "Candida-related denture stomatitis: a pilot study of the efficacy of an amorolfine antifungal varnish."

Related Drugs and Biologics

1.	Terbinafine (Lamisil)
2.	Ciclopirox (Loprox)
3.	Itraconazole (Sporanox)
4.	naftifine (naftifine hydrochloride)
5.	tioconazole
6.	efinaconazole
7.	yttrium-aluminum-garnet
8.	Erbium
9.	Griseofulvin (Grifulvin V)
10.	Clotrimazole (Lotrimin)

Related Therapies and Procedures

1.	Therapeutics
2.	Solid-State Lasers
3.	Gas Lasers
4.	Photochemotherapy (Photodynamic Therapy)
5.	Aftercare (After-Treatment)