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ZK 91296
structure in first source
Also Known As:
ZK-91296; ethyl 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-(methoxymethyl)-5-(phenylmethoxy)-, ethyl ester
Networked:
10
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Carbolines: 283
ZK 91296: 10
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Carbolines: 283
ZK 91296: 10
3-Ring Heterocyclic Compounds
Carbolines: 283
ZK 91296: 10
Related Diseases
1.
Seizures (Absence Seizure)
07/20/1984 - "
ZK 91296 1-16 mg/kg i.p.) attenuated the absence seizures without inducing signs of sedation or disorganized EEG patterns at any dose.
"
04/16/1985 - "
ZK 91296 protected mice from DMCM-induced seizures with high potency, this effect being benzodiazepine specific.
"
01/01/1989 - "
Two experimental AEDs, CGS 9896 and ZK 91296, with anticonvulsant action against PTZ- or DMCM-induced seizures were also included.
"
01/01/1984 - "
The lack of sedative effects, and the very potent inhibition of reflex epilepsy, spontaneous epilepsy and DMCM-induced seizures suggest, furthermore, that ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
"
09/01/1987 - "
Derivatives of ethyl-beta-carboline-3-carboxylate, ZK 91296, ZK 93423 and ZK 95962 have potent anticonvulsant activity against sound-induced seizures in audiogenic DBA/2 mice and against photically-induced seizures in the baboon, Papio papio.
"
2.
Reflex Epilepsy (Photosensitive Epilepsy)
07/22/1983 - "
The anticonvulsant action of ethyl-5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate (ZK 91296) has been studied in Senegalese baboons, Papio papio, with photosensitive epilepsy.
"
01/01/1984 - "
The lack of sedative effects, and the very potent inhibition of reflex epilepsy, spontaneous epilepsy and DMCM-induced seizures suggest, furthermore, that ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
"
3.
Epilepsy (Aura)
07/22/1983 - "
In this model of generalised epilepsy ZK 91296 is similar to diazepam in potency but has a longer duration of action.
"
01/01/1984 - "
The lack of sedative effects, and the very potent inhibition of reflex epilepsy, spontaneous epilepsy and DMCM-induced seizures suggest, furthermore, that ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
"
4.
Myoclonus (Nocturnal Myoclonus)
06/29/1984 - "
ZK 91296 and ZK 93423, suppress myoclonus with a potency at least as great as diazepam.
"
5.
Muscle Hypertonia
04/16/1985 - "
In mutant rats exhibiting an increased muscle tone of the hindlimbs, ZK 91296 was devoid of muscle relaxant effect and antagonised the muscle relaxant action of both diazepam and phenobarbitone.
"
Related Drugs and Biologics
1.
Diazepam (Valium)
2.
Anticonvulsants (Antiepileptic Drugs)
3.
Benzodiazepines
4.
ZK 93423
5.
methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate
6.
ZK 91296
7.
2- (4- chlorophenyl)- 2,5- dihydropyrazolo(4,3- c)quinoline- 3(3H)- one
8.
GABA-A Receptors (GABA(A) Receptor)
9.
Phenobarbital (Luminal)
10.
Lorazepam (Ativan)