elemene

07/28/2017 - "The bioassay results indicated that all of the target compounds exhibited significantly improved antiproliferative activities against three cancer cell lines (SGC-7901, HeLa and U87) compared to parent compound β-elemene. "
01/01/2022 - "β-Elemene, an effective anticancer component isolated from the Chinese herbal medicine Rhizoma Zedoariae, has been proved to have therapeutic potential against multiple cancers by extensive clinical trials and experimental research. "
11/01/2014 - "β-Elemene, a novel antitumor plant drug extracted from the traditional Chinese medicinal herb Zedoary, has been shown to be effective against a wide variety of tumors. "
12/01/2009 - "The therapeutic experiments showed that elemene is effective in treating cerebral malignancy."
01/01/2020 - "The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment."

01/01/2013 - "Overall, this study provides, to our knowledge, the first evidence showing that synthetic analogs of β-elemene hold promise for patients with brain tumors."
01/01/2013 - "In this study, we compared the cytotoxic efficacy of β-elemene and its synthetic analogs in the brain tumor cell lines A172, CCF-STTG1, and U-87MG. "
01/01/2013 - "Compared with β-elemene, only three of the 10 synthetic β-elemene analogs studied here, exerted comparable cytotoxic efficacy towards the three brain tumor lines: the analogs Lr-1 and Lr-2 had the same antitumor efficacy, while Lr-3 was less potent than β-elemene. "
01/01/2013 - "Anticancer activity of β-Elemene and its synthetic analogs in human malignant brain tumor cells."
09/01/2000 - "Elemene has significant effect on treatment of malignant brain tumor. "

02/01/2013 - "The aim of this study was to investigate whether β-elemene is able to repress the proliferation of T24 bladder carcinoma cells through regulation of the expression of the tumor suppressor gene, Smad4. "
11/01/2012 - "These results provide scientific evidence for further study on the anticancer effect of β-elemene in carcinoma of the urinary bladder. "
02/01/2013 - "β-elemene inhibits the proliferation of T24 bladder carcinoma cells through upregulation of the expression of Smad4."
01/01/2013 - "β-Elemene has been shown to have antiproliferative effects on many types of carcinomas. "
08/01/2012 - "β-Elemene is a natural plant product with broad-spectrum antitumor activity towards many types of carcinomas. "

03/01/2015 - "In this study, we showed that β-elemene inhibits human non-small cell lung carcinoma (NSCLC) cell growth, and increased phosphorylation of ERK1/2, Akt and AMPKα. "
01/01/2012 - "In this study, the antitumour effect of β-elemene on human non-small-cell lung cancer (NSCLC) A549 cells and the mechanism involved have been investigated. "
11/18/2023 - "Anoikis affects tumour development through various biological pathways in non-small cell lung cancer (NSCLC), but the regulation between β-elemene and anoikis remains to be explored. "
09/07/2023 - "β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). "
09/07/2023 - "β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer."

11/01/2018 - "In addition, there was an increased number of apoptotic bladder cancer cells following β-elemene treatment, and a significant reduction in cell invasion and migration. "
01/01/2020 - "Conclusions: The present study provided an effective strategy for the targeted delivery of β-elemene (β-E) to bladder cancer, and a combined strategy for bladder cancer treatment."
11/01/2018 - "Taken together, these results suggest that β-elemene has an antitumor effect in bladder cancer cells through the upregulation of PTEN and suppression of AKT phosphorylation."
11/01/2018 - "Subsequent western blot analyses revealed that bladder cancer cells treated with β-elemene had increased PTEN expression and decreased expression of pAKT. "
11/01/2018 - "β-elemene significantly suppressed the viability of bladder cancer cells, while leaving normal bladder cells unaffected. "