trimoprostil

01/01/1986 - "The effect of single 0.25 mg, 0.75 mg, 1.5 mg, and 3.0-mg oral doses of trimoprostil and placebo on the inhibition of meal-stimulated gastric acid secretion was investigated in duodenal ulcer patients. "
01/01/1986 - "Trimoprostil plasma concentration-gastric acid inhibition relationships in duodenal ulcer patients."
01/01/1986 - "An IC50 (plasma concentration needed to elicit a 50% inhibition effect) value of 0.2 ng/mL was observed at doses of 0.75 mg to 3.0 mg. Overall, trimoprostil was effective in inhibiting acid output in a dose-related manner in duodenal ulcer patients."
03/01/1988 - "In conclusion, trimoprostil was not as effective as cimetidine in the treatment of duodenal ulcer."
03/01/1988 - "A multicentre comparison of trimoprostil and cimetidine in the treatment of duodenal ulcer. "

12/01/1986 - "Furthermore, trimoprostil, at both doses, prevented the observed recurrence of this type of ulcer. "
12/01/1986 - "The higher two doses of trimoprostil accelerated the spontaneous healing of the ulcers. "
12/01/1986 - "Chronic gastric ulcers were produced by injection of 20% acetic acid (0.05 ml) into the submucosal layer of the rat stomach in order to determine the effects of the prostanoid trimoprostil on the healing and recurrence of ulcers. "
01/09/1989 - "The experience with arbaprostil, enprostil, misoprostol, rioprostil and trimoprostil shows that their effect on ulcer healing is superior to that of a placebo in acid inhibitory doses, which are also cytoprotective. "

01/01/1989 - "Patients treated with trimoprostil but not placebo experienced a significant reduction in the frequency (p less than 0.005) and duration (p less than 0.02) of heartburn. "

12/01/1986 - "Our present study suggests that trimoprostil is a promising antiulcer drug for the treatment of chronic gastric ulcer."
12/01/1986 - "Effects of trimoprostil on healing and recurrence of acetic acid-induced gastric ulcer in rats."
12/01/1986 - "Chronic gastric ulcers were produced by injection of 20% acetic acid (0.05 ml) into the submucosal layer of the rat stomach in order to determine the effects of the prostanoid trimoprostil on the healing and recurrence of ulcers. "
08/01/1983 - "Trimoprostil inhibited stress-induced gastric ulcer formation in rats more markedly than PGE2, cimetidine and sulpiride. "

01/01/1987 - "In nearly all trials natural prostaglandin E2 as well as the synthetic prostaglandin analogues arbaprostil, misoprostol, enprostil, rioprostil, trimoprostil, and rosaprostol accelerated the healing of peptic ulcers compared with placebo. "