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trimoprostil
RN refers to (5Z,11alpha,13E,15R)-isomer; structure in first source
Also Known As:
11,16,16-trimethyl PGE2; 11,16,16-trimethyl prostaglandin E2; 11,16,16-trimethyl-11-desoxyprostaglandin E2; Ro 21-6937; Ro-21-6937; TMD-PGE2
Networked:
8
relevant articles (
3
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
trimoprostil: 8
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
trimoprostil: 8
Related Diseases
1.
Duodenal Ulcer (Curling's Ulcer)
01/01/1986 - "
The effect of single 0.25 mg, 0.75 mg, 1.5 mg, and 3.0-mg oral doses of trimoprostil and placebo on the inhibition of meal-stimulated gastric acid secretion was investigated in duodenal ulcer patients.
"
01/01/1986 - "
Trimoprostil plasma concentration-gastric acid inhibition relationships in duodenal ulcer patients.
"
01/01/1986 - "
An IC50 (plasma concentration needed to elicit a 50% inhibition effect) value of 0.2 ng/mL was observed at doses of 0.75 mg to 3.0 mg. Overall, trimoprostil was effective in inhibiting acid output in a dose-related manner in duodenal ulcer patients.
"
03/01/1988 - "
In conclusion, trimoprostil was not as effective as cimetidine in the treatment of duodenal ulcer.
"
03/01/1988 - "
A multicentre comparison of trimoprostil and cimetidine in the treatment of duodenal ulcer.
"
2.
Ulcer
12/01/1986 - "
Furthermore, trimoprostil, at both doses, prevented the observed recurrence of this type of ulcer.
"
12/01/1986 - "
The higher two doses of trimoprostil accelerated the spontaneous healing of the ulcers.
"
12/01/1986 - "
Chronic gastric ulcers were produced by injection of 20% acetic acid (0.05 ml) into the submucosal layer of the rat stomach in order to determine the effects of the prostanoid trimoprostil on the healing and recurrence of ulcers.
"
01/09/1989 - "
The experience with arbaprostil, enprostil, misoprostol, rioprostil and trimoprostil shows that their effect on ulcer healing is superior to that of a placebo in acid inhibitory doses, which are also cytoprotective.
"
3.
Heartburn (Pyrosis)
01/01/1989 - "
Patients treated with trimoprostil but not placebo experienced a significant reduction in the frequency (p less than 0.005) and duration (p less than 0.02) of heartburn.
"
4.
Stomach Ulcer (Gastric Ulcer)
12/01/1986 - "
Our present study suggests that trimoprostil is a promising antiulcer drug for the treatment of chronic gastric ulcer.
"
12/01/1986 - "
Effects of trimoprostil on healing and recurrence of acetic acid-induced gastric ulcer in rats.
"
12/01/1986 - "
Chronic gastric ulcers were produced by injection of 20% acetic acid (0.05 ml) into the submucosal layer of the rat stomach in order to determine the effects of the prostanoid trimoprostil on the healing and recurrence of ulcers.
"
08/01/1983 - "
Trimoprostil inhibited stress-induced gastric ulcer formation in rats more markedly than PGE2, cimetidine and sulpiride.
"
5.
Peptic Ulcer (Peptic Ulcers)
01/01/1987 - "
In nearly all trials natural prostaglandin E2 as well as the synthetic prostaglandin analogues arbaprostil, misoprostol, enprostil, rioprostil, trimoprostil, and rosaprostol accelerated the healing of peptic ulcers compared with placebo.
"
Related Drugs and Biologics
1.
Acids
2.
Rioprostil
3.
Enprostil
4.
Misoprostol (Cytotec)
5.
Arbaprostil
6.
Dinoprostone (PGE2)
7.
Synthetic Prostaglandins (Prostaglandin Analogues)
8.
rosaprostol
9.
Cimetidine (Biomet)
10.
Acetic Acid (Vinegar)