cefpimizole

semisynthetic cephalosporin

Also Known As:

7 beta-D-alpha-(4(5)-carboxyimidazole-5(4)-carboxamido)phenylacetamido-3-(4-beta-sulfoethylpyridinium)methyl-3-cephem-4-carboxylic acid; AC 1370; AC-1370; U 63196 E; U-63196-E; U63196-E; cefpimizole sodium

Networked: 19 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - beta-Lactams: 2386
      - Cephalosporins: 4007
        cefpimizole: 19
- Sulfur Compounds: 278
  - Thiazines: 3
    - Cephalosporins: 4007
      - cefpimizole: 19
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - beta-Lactams: 2386
      - Cephalosporins: 4007
        cefpimizole: 19

Related Diseases

1.	Infections 12/01/1985 - "The therapeutic efficacy of AC-1370 against experimental infections in mice." 04/01/1985 - "In the treatment of 30 cases of gynecological infections, the clinical efficacy of AC-1370 was assessed as effective in all cases. " 04/01/1985 - "AC-1370 was effective in 20 out of 21 cases (95.2%) with gynecoobstetrical infections such as intrauterine, intrapelvic infection and mammitis, administered with 1 approximately 2 g twice a day. " 04/01/1985 - "In 1 patient treated with AC-1370 for postoperative infection, clinical findings, WBC and CRP improved: the drug was evaluated as effective. " 04/01/1985 - "AC-1370 was administered to 7 patients with gyneco-obstetrical infections, and the therapeutic efficacy was 85.7% (6 cases of 7 cases). "
2.	Gonorrhea 05/01/1986 - "Dose ranging study of cefpimizole (U-63196E) for treatment of uncomplicated gonorrhea in men." 05/01/1986 - "Results of the study demonstrate that cefpimizole offers no advantage over currently available antibiotics in the treatment of uncomplicated gonorrhea in men." 05/01/1986 - "We conducted a two-center dose ranging study to evaluate the efficacy, tolerance, and toxicity of cefpimizole, a new cephalosporin, in the treatment of uncomplicated gonorrhea in 96 males. " 04/01/1988 - "Thus, for acute uncomplicated gonorrhea cefpimizole is similar in efficacy to cefotaxime and APPG but has a higher frequency of pain at the injection site." 04/01/1988 - "Comparison of cefpimizole with cefotaxime and penicillin G for treatment of uncomplicated gonorrhea."
3.	Carcinoma (Carcinomatosis) 04/01/1985 - "Cefpimizole (AC-1370) concentrations in the pelvic dead space exudate were determined in patients under-going curative resection of carcinoma of the uterine cervix to study the transfer of the drug into the female genital organs, and the results were statistically analyzed, using the two-compartment model. "
4.	Pyometra 04/01/1985 - "AC-1370 was administered to 3 cases with pyometra, 1 case with Bartholin abscess, 1 case with adnexitis. "
5.	Pain (Aches) 04/01/1988 - "Pain at the injection site was reported by 52% of patients treated with cefpimizole as compared with 27% of those given cefotaxime (P = 0.008) and 17% of those given APPG (P = 0.002). " 04/01/1988 - "Thus, for acute uncomplicated gonorrhea cefpimizole is similar in efficacy to cefotaxime and APPG but has a higher frequency of pain at the injection site."

Related Drugs and Biologics

1.	Cephalosporins (Cephalosporin Antibiotics)
2.	Cefoperazone (Cefoperazone Sodium)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Cefotaxime (Kendrick)
5.	Probenecid (Benemid)
6.	Penicillin G Procaine (Procaine, Benzylpenicillin)
7.	Penicillin G (Benzylpenicillin)
8.	Ceftazidime (Fortum)
9.	Cefpirome (HR 810)
10.	Cefepime (Maxipime)

Related Therapies and Procedures

1.	Hysterectomy
2.	Lymph Node Excision (Lymph Node Dissection)
3.	Intravenous Injections
4.	Intravenous Infusions