mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase

removes alpha-1,3- & alpha-1,6-mannosyl residues during post-translational modification of glycoproteins; amino acid sequence of GmII (Drosophila) given in second source; GenBank X77652

Also Known As:

Networked: 47 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cook, Daniel: 3 articles (11/2016 - 07/2014)
2.	Gardner, Dale R: 3 articles (11/2016 - 07/2014)
3.	Pfister, James A: 3 articles (11/2016 - 07/2014)
4.	Kuntz, Douglas A: 3 articles (03/2010 - 10/2007)
5.	Rose, David R: 3 articles (03/2010 - 10/2007)
6.	Kóňa, Juraj: 2 articles (01/2016 - 03/2011)
7.	Tvaroška, Igor: 2 articles (01/2016 - 03/2011)
8.	Gerber-Lemaire, Sandrine: 2 articles (01/2010 - 10/2007)
9.	Moremen, Kelley W: 2 articles (07/2008 - 12/2002)
10.	Foo, Jhi Biau: 1 article (10/2021)

Related Diseases

1.	Colitis 03/16/2018 - "Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis."
2.	Neoplasms (Cancer) 10/01/2021 - "Targeting cancer via Golgi α-mannosidase II inhibition: How far have we come in developing effective inhibitors?" 03/01/2011 - "Human Golgi α-mannosidase II (hGM) is a pharmaceutical target for the design of inhibitors with anti-tumor activity. " 06/15/2001 - "Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells." 05/09/2023 - "The search for Golgi α-mannosidase II (GMII) potent and specific inhibitors has been a focus of many studies for the past three decades since this enzyme is a key target for cancer treatment. " 01/01/2020 - "Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan5GlcNAc2 to produce GlcNAcMan3GlcNAc2, the precursor for all complex N-glycans, including the branched N-glycans associated with cancer. "
3.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 12/19/2002 - "Corresponding studies on Golgi mannosidase II have employed swainsonine, an alkaloid natural plant product that causes "locoism", a phenocopy of the lysosomal storage disease, alpha-mannosidosis, as a result of the additional targeting of the broad-specificity lysosomal mannosidase by this compound. " 11/01/2016 - "Swainsonine, an indolizidine alkaloid, is an α-mannosidase and mannosidase II inhibitor that causes lysosomal storage disease and alters glycoprotein processing. " 08/01/2016 - "Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that causes lysosomal storage disease and alters glycoprotein processing. " 07/30/2014 - "Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that alters glycoprotein processing and causes lysosomal storage disease. "
4.	alpha-Mannosidosis 12/19/2002 - "Corresponding studies on Golgi mannosidase II have employed swainsonine, an alkaloid natural plant product that causes "locoism", a phenocopy of the lysosomal storage disease, alpha-mannosidosis, as a result of the additional targeting of the broad-specificity lysosomal mannosidase by this compound. "
5.	Neoplasm Metastasis (Metastasis) 06/15/2001 - "Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells." 01/29/1988 - "Swainsonine, an inhibitor of Golgi alpha-mannosidase II, has recently been shown to have potent antimetastatic activity in experimental metastasis assays. " 12/01/1991 - "However, another inhibitor of oligosaccharide processing, swainsonine, which inhibits mannosidase II activity and does not reduce metastasis, had no effect on platelet aggregation. " 07/01/1997 - "The indolizidine alkaloid swainsonine, a potent inhibitor of Golgi alpha-mannosidase II, has been shown to reduce tumor cell metastasis, enhance cellular immune responses, and reduce solid tumor growth in mice. "

Related Drugs and Biologics

1.	Swainsonine
2.	Mannosidases
3.	Alkaloids
4.	Enzymes
5.	Pyrrolidines
6.	Glycoproteins (Glycoprotein)
7.	alpha-Mannosidase (LAMAN)
8.	Polysaccharides (Glycans)
9.	Oligosaccharides
10.	Zinc

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)