Listeria monocytogenes hlyA protein (listeriolysin O)

from Listeria monocytogenes; ivanolysin O from L. ivanovii and seeligerolysin O from L. seeligeri have been sequenced (Biochim Biophys Acta 1992;1130(1):81-4); sulfhydryl-activated toxin; is able to lyse cholesterol containing membranes; can be reversibly inactivated by oxidation; cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes

Also Known As:

Networked: 166 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cossart, Pascale: 7 articles (01/2020 - 08/2012)
2.	Chakraborty, Trinad: 7 articles (01/2017 - 12/2002)
3.	Paterson, Yvonne: 6 articles (07/2009 - 05/2003)
4.	Mitsuyama, Masao: 5 articles (01/2022 - 07/2005)
5.	Tsuchiya, Kohsuke: 5 articles (01/2022 - 07/2005)
6.	Alvarez-Dominguez, Carmen: 4 articles (05/2022 - 02/2006)
7.	Hara, Hideki: 4 articles (01/2022 - 08/2007)
8.	Anderluh, Gregor: 4 articles (03/2021 - 01/2016)
9.	Deng, Xuming: 4 articles (01/2019 - 03/2015)
10.	Wang, Jianfeng: 4 articles (01/2019 - 03/2015)

Related Diseases

1.	Listeriosis (Listeria Infection) 01/01/2018 - "The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection." 08/01/2012 - "Listeriolysin O (LLO) is a toxin produced by Listeria monocytogenes, an opportunistic bacterial pathogen responsible for the disease listeriosis. " 03/01/2003 - "Use of listeriolysin O and internalin A in a seroepidemiological study of listeriosis in Swiss dairy cows." 02/12/1999 - "Cytotoxic T-cell, delayed type hypersensitive and listeriolysin O responses in experimental bovine listeriosis." 06/01/1993 - "Kinetics of antibody production against listeriolysin O in sheep with listeriosis."
2.	Neoplasms (Cancer) 01/01/2017 - "Axalimogene filolisbac (AXAL or ADXS11-001) is a novel immunotherapeutic based on the live, irreversibly attenuated Lm fused to the nonhemolytic fragment of listeriolysin O (Lm-LLO) and secretes the Lm-LLO-HPV E7 fusion protein targeting HPV-positive tumors. " 10/01/2009 - "Development of an Escherichia coli expressing listeriolysin-O vaccine against Wilms tumor gene 1-expressing tumors." 07/15/2009 - "We showed by electron microscopy that LM expressing truncated listeriolysin O (LLO) and amino acid fragments 311 to 660 of TAA Mage-b (LM-LLO-Mage-b(311-660)) and the control strain LM-LLO infect tumor cells in vitro and in vivo. " 10/01/2001 - "Using vaccinia virus as a live vector, we show that the expression of human papillomavirus type 16 (HPV-16) E7 fused to a nonhemolytic portion of the Listeria monocytogenes virulence factor, listeriolysin O (LLO), induces an immune response that causes the regression of established HPV-16 immortalized tumors in C57BL/6 mice. " 03/24/2021 - "The key feature of the cholesterol-dependent toxin listeriolysin O mutant (LLO Y406A) is its preferential activity at pH 5.7, which could be exploited either directly for selective targeting of cancer cells or the release of accumulated therapeutics from acidic endosomes. "
3.	Nervous System Diseases (Neurological Disorders) 01/01/2021 - "The present study evaluated the comparative serodiagnostic efficacy of recombinant listeriolysin-O (rLLO) and synthetic LLO- 2 peptide-based indirect ELISA vis-à-vis cultural isolation using samples (n = 1326; blood, sera, vaginal swabs, and rectal swabs) collected from caprines (n = 350) and ovines (n = 50) having reproductive and/or nervous system disorders and/or healthy animals. "
4.	Lymphoma (Lymphomas) 04/01/2008 - "In this study we investigated whether an alternate carrier, Listeriolysin O (LLO), would amplify the immune response to Id protein and provide better protection against challenge by 38C13 murine lymphoma. " 04/01/2008 - "Listeriolysin O is an improved protein carrier for lymphoma immunoglobulin idiotype and provides systemic protection against 38C13 lymphoma."
5.	Vaccinia 12/15/2004 - "Previous work in our laboratory has established that the fusion of tumor-associated antigens to a truncated form of the Listeria monocytogenes virulence factor listeriolysin O (LLO) enhances the immunogenicity and antitumor efficacy of the tumor antigen when delivered by Listeria or by vaccinia. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Proteins (Proteins, Gene)
3.	Vaccines
4.	Gold
5.	Virulence Factors (Pathogenicity Factors)
6.	Antigens
7.	Neoplasm Antigens (Tumor Antigens)
8.	Immunoglobulin Idiotypes (Idiotype, Immunoglobulin)
9.	Carrier Proteins (Binding Protein)
10.	delta inulin

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Positive-Pressure Respiration (Positive End-Expiratory Pressure)
4.	Microspheres (Microsphere)