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Ro 14-7437

benzodiazepine antag; no other info available 8/16/83

Also Known As:

Ro-14-7437

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Ro 14-7437: 2

Related Diseases

1.	Brain Diseases (Brain Disorder) 09/01/1993 - "Encephalopathy was significantly improved by Ro 15-4513, although Ro 14-7437 and vehicle had no effect. "
2.	Hepatic Encephalopathy 07/01/1988 - "In addition, incubation of Purkinje neurons from rabbits with hepatic encephalopathy with subthreshold concentrations of Ro 14-7437 reduced their sensitivity to muscimol, whereas treatment of control neurons with Ro 14-7437 had no effect on their sensitivity to muscimol. " 09/01/1993 - "The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested. " 07/01/1988 - "Furthermore, qualitatively different responses of Purkinje neurons to benzodiazepine receptor antagonists (Ro 15-1788 and Ro 14-7437) were found in controls and rabbits with hepatic encephalopathy. "

Related Drugs and Biologics

1.	Ro 15-4513
2.	GABA-A Receptors (GABA(A) Receptor)
3.	Muscimol
4.	Flumazenil (Romazicon)
5.	methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate