nafimidone

11/01/1985 - "Efficacy of nafimidone in the treatment of intractable partial seizures: report of a two-center pilot study."
01/01/1988 - "Nafimidone did not significantly elevate seizure thresholds at the doses tested; however, nafimidone (3.1-50 mg/kg) reduced the severity and afterdischarge duration of threshold elicited seizures in a non-dose response manner. "
09/01/1986 - "This agent was twice as potent as nafimidone in inhibiting maximal electroshock seizures in mice (po ED50's = 25 and 56 mg/kg, respectively) and considerably less toxic in the rat (po LD50's = 4550 and 504 mg/kg, respectively). "
01/01/1988 - "This study has demonstrated that although nafimidone can modify both threshold and suprathreshold elicited kindled amygdaloid seizures, it lacks significant specificity in this model of epilepsy."
06/01/1987 - "Nafimidone is a new antiepileptic drug which may be effective in partial onset seizures. "

01/01/2022 - "Potential of nafimidone derivatives against co-morbidities of epilepsy: In vitro, in vivo, and in silico investigations."
01/01/1988 - "This study has demonstrated that although nafimidone can modify both threshold and suprathreshold elicited kindled amygdaloid seizures, it lacks significant specificity in this model of epilepsy."
03/01/2013 - "Nafimidone derivatives may be effective in the cases where epilepsy and diabetes occur together since it has shown efficacy against "loss of sensation" which evolves in diabetic neuropathy over time as well as its antiepileptic effect."

03/01/2013 - "Evaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathy."
03/01/2013 - "Nafimidone derivatives may be effective in the cases where epilepsy and diabetes occur together since it has shown efficacy against "loss of sensation" which evolves in diabetic neuropathy over time as well as its antiepileptic effect."

03/01/2013 - "At this study, we evaluated the effect of three different nafimidone derivatives which have possible anticonvulsant activity on disorders of thermal pain sensation in diabetic mice. "

06/01/1987 - "Pharmacokinetics of nafimidone in patients with chronic intractable epilepsy."