epanolol

structure given in first source

Also Known As:

ICI 141,292; ICI 141292; ICI-141,292; N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxyphenylacetamide; Visacor; Benzeneacetamide, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxy-

Networked: 34 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Stable Angina 03/01/1990 - "2. The pharmacokinetics of epanolol have been studied over 72 h after a single oral dose of 200 mg and then over 24 h after 12 consecutive daily oral doses in 13 elderly patients with stable angina pectoris. " 03/01/1990 - "Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris." 02/01/1990 - "Pharmacokinetics of epanolol in elderly patients with stable angina pectoris." 01/01/1989 - "We conclude that, in this study, epanolol is as effective as atenolol as an antianginal agent for chronic stable angina. " 01/01/1989 - "Comparative multicentre study of the tolerability and efficacy of epanolol versus nifedipine in patients with stable angina pectoris."
2.	Angina Pectoris 01/01/1989 - "Epanolol is a new once-daily agent for the treatment of angina pectoris. " 01/01/1991 - "Effects of a single oral administration of Epanolol on exercise tolerance in patients with stable effort angina pectoris." 01/01/1992 - "Efficacy of epanolol versus metoprolol in angina pectoris: report from a Swedish multicentre study of exercise tolerance." 01/01/1989 - "Efficacy of epanolol versus metoprolol in angina pectoris. " 08/01/1992 - "Comparative effects of epanolol and diltiazem on exercise performance and respiratory gas exchange in angina pectoris."
3.	Asthma (Bronchial Asthma) 01/01/1986 - "To study its cardioselectivity in humans, comparable beta-blocking doses of 200 mg ICI 141,292 and 100 mg atenolol were given to 12 patients with stable bronchial asthma. " 01/01/1986 - "Assessment of the relative safety of the beta-blockers ICI 141,292 and atenolol in patients with bronchial asthma."
4.	Essential Hypertension 04/01/1988 - "The effect of epanolol on intra-arterial ambulatory blood pressure and baroreceptor heart rate reflex in essential hypertension." 01/01/1985 - "The first dose hemodynamic responses to Visacor (ICI 141-292) in essential hypertension." 12/01/1984 - "Fifty-nine patients with mild essential hypertension were randomized to two of five treatment alternatives (placebo, 50 mg, 100 mg 200 mg or 300 mg of ICI 141,292) each given once daily for 2 weeks with a 4 week placebo period before (run in) and in between (wash out) active periods. " 02/01/1993 - "Epanolol, a selective beta 1-receptor blocker with intrinsic sympathomimetic activity, induced a fall in intraarterial pressure of 8% at rest sitting and 11% during 100 W bicycle exercise after the first dose of 200 mg in 12 patients with essential hypertension. " 08/01/1987 - "1 Eight men with primary hypertension were treated for 3 weeks with placebo, epanolol (200 mg or 400 mg), or atenolol 100 mg in a randomised cross-over study. "
5.	Tachycardia (Tachyarrhythmias) 01/01/1989 - "Evidence is available which shows that attenuation of the tachycardia of exercise persists for 24 hours after a single dose of epanolol 200mg, a dose which retains selectivity for the beta 1-adrenoceptor. " 08/01/1987 - "3 The reduction of exercise-induced tachycardia by epanolol 400 mg was comparable to that of atenolol. " 03/01/1986 - "The maximum percent reduction of an exercise tachycardia after ICI 141,292 200 mg (23.9 +/- 3.7%) and 400 mg (24.3 +/- 5.2%) were similar to atenolol 50 mg (27.3 +/- 4.7%) but less than atenolol 100 mg (30.8 +/- 2.9%) (P less than 0.02). " 03/01/1986 - "Effects of ICI 141,292 on exercise tachycardia and isoprenaline-induced beta-adrenoceptor responses in man."

Related Drugs and Biologics

1.	Metoprolol (Toprol-XL)
2.	Atenolol (Tenormin)
3.	Nifedipine (Adalat)
4.	Sympathomimetics (Sympathomimetic Amines)
5.	epanolol
6.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)
7.	Propranolol (Inderal)
8.	acetamide
9.	Diltiazem (Cardizem)
10.	Doxazosin (Cardura)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Sodium-Restricted Diet (Diet, Sodium Restricted)
4.	Oral Administration