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CP 46665

immunomodulator; RN given refers to di-HCl

Also Known As:

4-aminomethyl-1-(2,3-bis(decyloxy)propyl)-4-phenylpiperidine; CP 46665-1; CP-46,665

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - CP 46665: 6

Related Diseases

1.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 12/01/1987 - "CP-46,665 failed to show therapeutic efficacy in 3-Lewis lung carcinoma (3-LL) growing in syngeneic C57Bl6-mice, in methylnitrosourea (MNU)-induced rat mammary carcinomas and in 2 human non-seminomatous germ cell tumor cell lines (H 12.1, H 12.7) growing in nu/nu NMRI-mice when given in a dose range including non-toxic doses and doses higher than the lethal dose for 10% of the treated animals (LD10)."
2.	Carcinoma (Carcinomatosis) 12/01/1987 - "CP-46,665 failed to show therapeutic efficacy in 3-Lewis lung carcinoma (3-LL) growing in syngeneic C57Bl6-mice, in methylnitrosourea (MNU)-induced rat mammary carcinomas and in 2 human non-seminomatous germ cell tumor cell lines (H 12.1, H 12.7) growing in nu/nu NMRI-mice when given in a dose range including non-toxic doses and doses higher than the lethal dose for 10% of the treated animals (LD10)."
3.	Neoplasms (Cancer) 04/01/1986 - "CP-46,665 suppressed the colony formation of various human tumors with a slight dose response relation after 1 hr incubation and with a clear optimum (85% response rate) after continuous exposure in the higher dose range tested (10 micrograms/ml). " 03/01/1985 - "These effects on thymidine uptake and single cell viability were accompanied by a clear loss of the reproductive capacities of human tumor and leukemic cells as measured in a human tumor stem cell assay after incubation with CP-46,665. " 12/01/1987 - "Lack of therapeutic activity of the lipoidal amine CP-46,665 in rodent tumors and human non-seminomatous germ cell tumors growing in nude mice." 04/01/1986 - "The antineoplastic activity of two ether lipid derivatives, the alkyl-lysophospholipid derivative (ALP) ET-18-OCH3 and the ether-linked lipoidal amine CP-46,665 was tested in a human tumor clonogenic assay (HTCA) in vitro. "
4.	Wounds and Injuries (Trauma) 05/01/1987 - "The only exception was with high-dose CP-46,665, which produced weakened wounds on day 14 (p less than 0.05) and 21 (p less than 0.01). "
5.	Leukemia 11/01/1987 - "The effects of 2-lysophosphatidylcholine (2-LPC), the alkyl lysophospholipid derivatives (ALP) 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-O-hexadecyl-sn-glycero-3-phospho-trimethyl-ammonio-hexanol, the 2-acetamide analog of platelet-activating factor (PAF) 1-O-octadecyl-2-acetamide-sn-glycero-3-phosphocholine, the thioether lysophospholipid derivative (TLP) BM 41.440 and the ether-linked lipoidal amine CP-46,665 on tritiated thymidine uptake and trypan blue dye exclusion were tested in vitro in various freshly explanted cell samples from human nonneoplastic bone marrow and human leukemias. "

Related Drugs and Biologics

1.	Methylnitrosourea (N-Methyl-N-nitrosourea)
2.	Amines
3.	Thymidine
4.	Lysophospholipids
5.	Ether (Diethyl Ether)
6.	edelfosine
7.	Thymopentin
8.	Trypan Blue
9.	Sulfides (Thioethers)
10.	Platelet Activating Factor