neuromedin B

decapeptide isolated from porcine spinal cord

Also Known As:

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2; glycyl-arginyl-leucyl-tryptophyl-alanyl-threonyl-glycyl-histidyl-phenylalanyl-methioninamide; Ranatensin, 1-glycine-2-L-asparagine-3-L-leucine-4-de-L-glutamine-7-L-threonine-

Networked: 64 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jensen, Robert T: 3 articles (07/2010 - 06/2002)
2.	Ko, Mei-Chuan: 2 articles (01/2022 - 05/2019)
3.	Bae, Moon-Kyoung: 2 articles (11/2021 - 12/2011)
4.	Bae, Soo-Kyung: 2 articles (11/2021 - 12/2011)
5.	Kim, Mi-Kyoung: 2 articles (11/2021 - 12/2011)
6.	Park, Hyun-Joo: 2 articles (11/2021 - 12/2011)
7.	Luo, Wenqin: 2 articles (01/2021 - 07/2012)
8.	Biemond, I: 2 articles (10/2011 - 10/2004)
9.	Moody, Terry W: 2 articles (07/2010 - 02/2008)
10.	Archimandritis, S: 2 articles (05/2002 - 05/2002)

Related Diseases

1.	Obesity 01/01/2022 - "Altogether, the study reinforces the hypothesis that inhibition of NB-NBR signaling enhances the capacity for oxidative phosphorylation of white SM, encouraging future studies to elucidate their contribution on other types of SM and whole body energy expenditure, which may lead to a new target to drug development for obesity treatment.NEW & NOTEWORTHY This study describes neuromedin B (NB) and NB receptor as new regulators of skeletal muscle mitochondrial function. " 03/01/2010 - "Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study." 07/23/2013 - "Rs2292462 lies within the obesity-implicated neuromedin B gene. " 05/01/1991 - "4. These findings suggest that disturbances in hypothalamic neuromedin B concentrations may be involved in the obesity syndrome of the fa/fa Zucker rat. "
2.	Neoplasms (Cancer) 02/15/1997 - "Potency studies also revealed GRP > > bombesin > > neuromedin B at elevating [Ca2+]i in responding tumor cells. " 02/01/2008 - "Neuromedin B/BB1-receptor is an important physiological regulator of pituitary-thyroid function; in mediating behavior, especially feas/anxiety; in mediating satiety through different cascades than gastrin-releasing peptide/BB2 receptors and for its autocrine tumor-growth effects. " 09/28/2001 - "RT-PCR analyses revealed that the expression of mRNA for receptors of GRP (GRPR/BRS-1) and Neuromedin B (NMBR/BRS-2) on tumors was significantly decreased in all the treated groups. " 08/15/1990 - "No transcription of either GRP or neuromedin B mRNA could be shown in tumor or normal cells. " 01/01/1988 - "Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors."
3.	Body Weight (Weight, Body) 01/01/2000 - "Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents." 02/01/1997 - "Here, we aimed to determine if the pituitary content of neuromedin B would change in fasted rats (1, 2, 3, and 4 days of food deprivation) and streptozotocin (55 mg/kg body weight)-diabetic rats. " 05/01/2010 - "Previous studies have proposed a role for neuromedin B (NB), a bombesin-like peptide, in the control of body weight homeostasis. " 01/01/2022 - "Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide."
4.	Gastrinoma 12/01/1990 - "A study relating to gastrin release from gastrinoma cells by neuromedin B and C-terminal decapeptide of gastrin releasing peptide (GRP-10) has not yet been reported. " 11/01/1996 - "The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). " 12/01/1990 - "Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma."
5.	Infections 10/10/2019 - "Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo." 06/27/1995 - "In binding studies the affinity of the mGRP-r in Sf9 cells for the agonists bombesin (Bn), GRP, and neuromedin B (NMB) varied differently with infection time: with Bn the affinity decreased 3-fold with longer infection times, with GRP it remained unchanged, and with NMB it decreased 10-fold. "

Related Drugs and Biologics

1.	Bombesin
2.	Peptides (Polypeptides)
3.	Gastrin-Releasing Peptide
4.	Gastrins
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Neuropeptides
7.	Bombesin Receptors (Bombesin Receptor)
8.	Thyrotropin (Thyroid-Stimulating Hormone)
9.	Messenger RNA (mRNA)
10.	Insulin (Novolin)