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ethylenediamine platinum(II) malonate (JM 40)
Also Known As:
JM 40
; JM-40; NSC 146068; NSC-146,068; malopen; Platinum, (1,2-ethanediamine-N,N')(propanedioato(2-)-O,O')-, (SP-4-2)-
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organometallic Compounds: 64
Organoplatinum Compounds
ethylenediamine platinum(II) malonate: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1985 - "
Cisplatin and carboplatin caused some growth delay of Pe, while JM-40, spiroplatin, and iproplatin failed to affect tumor growth.
"
12/01/1989 - "
A randomized double-blind study was conducted to compare the anti-emetic efficacy of 1 mg/kg vs 2 mg/kg metoclopramide, administered 5 times over a period of 8.5 h in 50 cancer patients treated with platinum-containing regimens (cisplatin, ethylenediamine platinum II malonate or spiroplatin).
"
01/01/1985 - "
Platinum concentrations in the two tumors at 24 hr were similar for cisplatin and carboplatin, but differed for iproplatin, spiroplatin, and JM-40.
"
2.
Vomiting
08/01/1987 - "
Vomiting in order of severity occurred after TNO-6, CHIP, CDDP and JM-40, while CBDCA did not cause any vomiting.
"
12/01/1989 - "
However, in the group of patients who received a high dosage of cisplatin (70-100 mg/m2), or ethylenediamine platinum II malonate (800-900 mg/m2), there was a significant difference in nausea and vomiting between patients who had and those who had not received prior chemotherapy, most probably due to anticipation.
"
3.
Proteinuria
08/01/1987 - "
JM-40 did not cause significant proteinuria.
"
4.
Nausea
12/01/1989 - "
However, in the group of patients who received a high dosage of cisplatin (70-100 mg/m2), or ethylenediamine platinum II malonate (800-900 mg/m2), there was a significant difference in nausea and vomiting between patients who had and those who had not received prior chemotherapy, most probably due to anticipation.
"
Related Drugs and Biologics
1.
spiroplatin
2.
Platinum
3.
Cisplatin (Platino)
4.
Metoclopramide (Reglan)
5.
Antiemetics
6.
Carboplatin (JM8)
7.
iproplatin (JM9)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)