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NCO 650
RN given refers to (trans)-isomer
Also Known As:
GMCHA-OPhBu; GMCHA-OPhBu(t); NCO 650, monohydrochloride, (trans)-isomer; NCO-650; trans-4-guanidinomethylcyclohexanecarboxylic acid tert-butylphenyl ester
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexanecarboxylic Acids
NCO 650: 2
Carboxylic Acids: 973
Carbocyclic Acids
Cyclohexanecarboxylic Acids
NCO 650: 2
Related Diseases
1.
Asthma (Bronchial Asthma)
01/01/1987 - "
The above findings show that NCO-650 may be useful for the treatment of bronchial asthma as an orally active drug.
"
2.
Hemolysis
11/01/1984 - "
NCO-650 was found to show the greatest hemolysis protection, reduction of the surface tension and depression of the phase-transition temperature, indicating that it possesses a significant affinity to cell membranes and a significant ability to stabilize cell membranes.
"
11/01/1984 - "
Disodium cromoglycate and tranilast showed neither cell membrane affinity nor hemolysis protection, although they inhibit histamine release from mast cells like NCO-650 and its congeners.
"
11/01/1984 - "
NCO-650 and its congeners and two other antiallergics, disodium cromoglycate and tranilast, were studied to determine the degree of protection of rat erythrocytes against hypotonic hemolysis, the reduction of the surface tension of dipalmitoylphosphatidylcholine (DPPC) monolayer and the depression of the phase-transition temperature of DPPC liposome bilayers.
"
Related Drugs and Biologics
1.
Anti-Allergic Agents (Antiallergic Agents)
2.
1,2-Dipalmitoylphosphatidylcholine (Dipalmitoylphosphatidylcholine)
3.
Liposomes (Liposome)
4.
Cromolyn Sodium (Cromoglicic Acid)
5.
tranilast