methylmethacrylate-methacrylic acid copolymer

methacrylic acid polymer with methyl methacrylate

Also Known As:

Eudragit; Eudragit 12,5P; Eudragit L; Eudragit L 30 D; Eudragit L-100; Eudragit S; Eudragit S-100; MMA-MAA polymer; PMMA-MA; PMMA-MAA; Vitan-2M; eudispert; eudragits; poly(methylmethacrylate-co-methacrylic acid); polymethacrylic acid methyl ester

Networked: 137 relevant articles (20 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Machida, Yoshiharu: 3 articles (06/2008 - 08/2007)
2.	Onishi, Hiraku: 3 articles (06/2008 - 08/2007)
3.	Oosegi, Tomoko: 3 articles (06/2008 - 08/2007)
4.	McGinity, James W: 3 articles (08/2007 - 10/2003)
5.	Vyas, Bhavin: 2 articles (08/2021 - 05/2018)
6.	Caddeo, Carla: 2 articles (01/2021 - 02/2019)
7.	Fernàndez-Busquets, Xavier: 2 articles (01/2021 - 02/2019)
8.	Manconi, Maria: 2 articles (01/2021 - 02/2019)
9.	Bendas, Ehab R: 2 articles (11/2016 - 04/2010)
10.	Bhalekar, Mangesh R: 2 articles (01/2016 - 10/2011)

Related Diseases

1.	Ulcerative Colitis 06/10/2023 - "Comparison of 5-ASA layered or matrix pellets coated with a combination of ethylcellulose and eudragits L and s in the treatment of ulcerative colitis in rats." 04/28/2023 - "Achillea wilhelmsii-Incorporated Chitosan@Eudragit Nanoparticles Intended for Enhanced Ulcerative Colitis Treatment." 11/01/2004 - "The short-term effects of Eudragit-L-coated prednisolone metasulphobenzoate (Predocol) on bone formation and bone mineral density in acute ulcerative colitis." 02/01/1992 - "Prednisolone metasulphabenzoate coated with Eudragit S (30-60 mg daily) was then administered for 12 weeks to 12 patients with colonoscopically proven extensive ulcerative colitis in relapse. " 04/01/2006 - "Eudragit-L and ethylcellulose-coated mesalazine tablets are well tolerated and equally effective in achieving remission in mild-moderately active ulcerative colitis over 8 weeks."
2.	Colitis 01/01/2023 - "The results demonstrated that TJ-5/MCN/DSS/Eudragit not only achieved delayed drug release and improved colon targeting but also exhibited optimal therapeutic efficacy in colitis mice. " 02/01/2023 - "This study constructed a targeted delivery system for experimental colitis, namely, eudragit (EuL)-coated chitosan (Ch)-TG conjugate microspheres (Ch-TG-MS/EuL), and evaluated its therapeutic efficacy and underlying mechanisms. " 12/15/2022 - "In this study, we used biosynthesized PHB combined with Eudragit FS (EFS) and cyclosporine A (CSA) to develop pH-responsive controlled CSA-releasing nanoparticles (CSA-PENPs) for colitis-targeted drug delivery and demonstrated its enhanced therapeutic efficacy in a dextran sulfate sodium (DSS)-induced murine colitis model. " 01/01/2022 - "Es wurde eine zusammenfassende Analyse der drei bisher veröffentlichten klinischen Studien mit 160 eingeschlossenen Colitis-ulcerosa-Patienten durchgeführt.Ergebnisse und Schlussfolgerung: Die Metaanalyse zeigte, dass mit Phosphatidylcholin angereichertes und mit Eudragit S-100 mikroverkapseltes Lecithin die Remissionsrate sowie das klinische und endoskopische Bild deutlich verbessert. " 02/01/2023 - "Eudragit-coated chitosan-tripterygium glycoside conjugate microspheres alleviate DSS-induced experimental colitis by inhibiting the TLR4/NF-κB signaling pathway."
3.	Crohn Disease (Crohn's Disease) 01/01/1992 - "It is concluded that oral 5-ASA coated with Eudragit S (Rohn Pharma GmbH, Wieterstadt, Germany), 2.4 g daily, is safe and seems superior to placebo in preventing or delaying clinical relapse in Crohn's disease, especially in milder cases and in ileal disease." 06/29/2007 - "From the results of this investigation, the application of double microencapsulation technique employing PLGA matrix and Eudragit S-100 coating shows promise for site specific and controlled delivery of budesonide in Crohn's disease." 11/01/1999 - "Clinical efficacy has been demonstrated for Eudragit-L-coated tablets even at a low dose of 1-1.5 g 5-ASA/day in the maintenance treatment of remission of Crohn's disease. " 11/01/1999 - "4.5 g Eudragit-L-coated 5-ASA tablets are almost equally as potent as glucocorticosteroids for the treatment of active Crohn's disease. " 07/01/1999 - "In conclusion, intraluminal pH is not decreased by inflammatory changes in Crohn's disease and ulcerative colitis, allowing eudragit-coated pH-controlled-release formulations of mesalazine to dissolve in diseased areas also."
4.	Weight Gain 10/01/2023 - "The Box-Behnken design was utilized, where the selected independent variables were the proportion of CM tamarind gum, % water proportion, and % weight gain of Eudragit S 100 to optimize the formulation. " 01/01/2009 - "Results showed that Eudragit L30D-55 with 3% weight gain accompanied with TEC produced suitable enteric coated pellets." 06/05/2008 - "A lag time could therefore be controlled by manipulating both the theoretical weight gain of the beads and the concentration of Eudragit NE 30D in the blend." 01/30/2016 - "Tablets were prepared by direct compaction and coated with aqueous dispersions of Eudragit(®) L30 D-55, Eudragit(®) EPO, Opadry(®) AMB and Sepifilm(®) LP at the vendors' recommended weight gains. " 01/01/2016 - "The spray dried SMEDDS were filled in capsules which were enteric coated with Eudragit S-100 at 10% weight gain to ensure SMEDDS delivery at colon. "
5.	Colonic Neoplasms (Colon Cancer) 01/01/2014 - "This study was set to examine the potential effects of three Eudragits RL100, S100 and L100 on the intestinal epithelial membrane transport of rhodammine-123 (Rho-123), a substrate of P-gp using a monolayer of human colon cancer cell line (Caco-2). " 04/24/2020 - "In conclusion, SMV-loaded chitosan coated with eudragit S100 formula exhibited improved colon targeting and enhanced cytotoxicity and proapoptotic activity against HCT-116 colon cancer cells." 12/01/2022 - "Herein, we report redox responsive, colon cancer targeting poly(allylamine) (PA)/eudragit S-100 (EU) nanoparticles (PAEU NPs) (≈59 nm). " 01/01/2020 - "In this article, a new approach to non-invasive monitoring of drug release from a delivery vehicle via MRI was developed, using pH-responsive Eudragit L100 and S100 fibres encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) and carmofur (a drug used in the treatment of colon cancer). " 08/12/2021 - "Hence, it was aimed to employ Eudragit S100 surface engineered 5-FU nanostructured lipid carriers for the spatial and temporal release of the drug for the treatment of colon cancer. "

Related Drugs and Biologics

1.	Mesalamine (Mesalazine)
2.	Tablets
3.	Chitosan
4.	olsalazine (Dipentum)
5.	Prednisolone (Predate)
6.	Polysaccharides (Glycans)
7.	Sulfasalazine (Azulfidine)
8.	Cyclosporine (Ciclosporin)
9.	Dextran Sulfate
10.	Silymarin

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Enema (Enemas)
3.	Therapeutics
4.	Chronotherapy
5.	Drug Therapy (Chemotherapy)