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heparanase

mammalian endoglucuronidase which degrades heparan sulfate glycosaminoglycans into short 5-6 kDa pieces; RefSeq NM_021828 (HPSE2, human); NM_022605 (rat); NM_152803 (mouse); NM_006665 (HPSE, human)

Also Known As:

HPSE protein, human; HPSE2 protein, human; Hpr1 protein, mouse; Hpse protein, mouse; Hpse protein, rat; endoglycosidase heparanase, mouse; heparan sulfate endoglycosidase; heparan sulphate endoglycosidase; heparanase 2 protein, human; heparanase 3 protein, human; heparanase, human; heparanase, mouse; heparanase, rat

Networked: 740 relevant articles (20 outcomes, 145 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Glycoside Hydrolases: 275
      - Glucuronidase: 1534
        heparanase: 740

Experts

1.	Vlodavsky, Israel: 142 articles (01/2016 - 01/2002)
2.	Ilan, Neta: 77 articles (09/2015 - 05/2002)
3.	Zcharia, Eyal: 34 articles (06/2014 - 04/2002)
4.	Vlodavsky, I: 27 articles (08/2015 - 06/2000)
5.	Sanderson, Ralph D: 25 articles (01/2015 - 12/2003)
6.	Elkin, Michael: 22 articles (12/2014 - 04/2002)
7.	Marchetti, Dario: 21 articles (05/2015 - 07/2002)
8.	Li, Jin-Ping: 20 articles (01/2015 - 05/2005)
9.	Nakajima, Motowo: 20 articles (10/2012 - 11/2002)
10.	Nadir, Yona: 19 articles (12/2015 - 10/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/22/2007 - "Our results suggest that genetic downregulation of the expression of heparanase may serve as an efficient cancer therapeutic for human HCC." 03/09/2012 - "Although heparanase (HPA) is a potential target for patients with advanced tumor diseases, the efficacy of immunotherapeutic strategies targeting HPA has never been evaluated. " 08/01/2015 - "Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model." 12/22/2015 - "The present study was aimed to evaluate heparanase procoagulant activity in myeloproliferative neoplasms. " 01/01/2015 - "The study shows that salivary heparanase levels, as detected by the ELISAs, can be used to diagnose and provide an accurate prognosis for malignant salivary gland tumors. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2008 - "This study is to learn the correlation between lymph-node metastasis and the combined expression of Heparanase (Hpa) and C-erbB-2. " 04/01/2015 - "Biochemical analysis indicated that the invertebrate glycan also inhibits heparanase, a key player in cell invasion and metastasis. " 09/02/2014 - "Heparanase is implicated in cell invasion, tumour metastasis and angiogenesis. " 01/01/2014 - "Heparanase is an endoglycosidase enzyme present in activated leucocytes, mast cells, placental tissue, neutrophils and macrophages, and is involved in tumour metastasis and tissue invasion. " 01/18/2012 - "Previous work has demonstrated that heparanase plays important roles in various biological processes including angiogenesis, wound healing and metastasis. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "The aim of this study is to determine the differential regulation of heparanase gene expression in specific stages of breast cancer by DNA methylation. " 07/15/2007 - "The present study was undertaken to elucidate molecular mechanisms responsible for heparanase overexpression in breast cancer. " 06/01/2007 - "PBMC samples from all breast cancer patients at study entry showed the expression of heparanase, whereas no expression was observed for healthy women. " 04/01/2006 - "The present study was undertaken to investigate the role of heparanase in local growth and angiogenesis of primary breast tumors. " 11/01/2004 - "This study was to investigate correlation of heparanase expression to angiogenesis and prognosis of breast cancer. "
4.	Stomach Neoplasms (Stomach Cancer) 04/01/2010 - "Given that previous studies indicated that early growth response 1 (EGR1) exerts pro-tumorigenic effects through regulating heparanase (HPA) transcription, it was hypothesized that EGR1 may correlate with the progression of gastric cancer. " 01/01/2010 - "The aim of this study is to determine whether silencing of heparanase expression can abolish the malignant characteristics of gastric cancer cells. " 01/01/2010 - "Our studies indicated that heparanase was frequently expressed in advanced gastric cancers. " 01/01/2014 - "These data suggest that heparanase facilitates invasion and migration of human gastric cancer cells probably through elevating phosphorylation of Src and p38. " 01/01/2014 - "We first evaluated the endogenous expression of heparanase in human gastric cancer cell lines and found Heparanase expression higher in SGC-7901 than MGC-803. "
5.	Carcinoma (Carcinomatosis) 04/01/2013 - "In the present study we evaluated the role of heparanase promoter methylation in colon carcinoma. " 10/01/2012 - "The aim of this study was to investigate the expression patterns of heparanase and COX-2 during progression of oral epithelial dysplasia (OED) to carcinoma. " 02/01/2015 - "Heparanase 1 is more intensely expressed in the glandular tissue of high-grade compared with type I carcinomas. " 12/07/2014 - "Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. " 12/01/2014 - "Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme."

Related Drugs and Biologics

1.	Heparin (Liquaemin)
2.	Heparitin Sulfate (Heparan Sulfate)
3.	Carbon Monoxide
4.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
5.	Glucuronidase
6.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
7.	Syndecan-1 (Syndecan 1)
8.	Small Interfering RNA (siRNA)
9.	Conditioned Culture Media
10.	heparitinsulfate lyase

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Homologous Transplantation (Allograft)
3.	Immunotherapy
4.	Lasers (Laser)
5.	Radiotherapy