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ganglio-N-triaosylceramide
tumor associated marker for L5178 cells
Also Known As:
G(A(2)) Ganglioside; G(A2) ganglioside; GA(2) Ganglioside; GA2 ganglioside; GalNAc beta1-4Gal beta1-4Glc beta1-1Cer; acetylgalactosaminyl-1-4-galactosyl-1-4-glucosyl-1-1-ceramide; asialo GM2; gangliotriosylceramide; glycolipid G(A2); Ganglioside GA2
Networked:
11
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Glycoconjugates: 1353
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
ganglio-N-triaosylceramide: 11
Lipids: 114793
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
ganglio-N-triaosylceramide: 11
Membrane Lipids: 1591
Sphingolipids: 3208
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
ganglio-N-triaosylceramide: 11
Experts
1.
Buccoliero, R
: 1 article (11/2007)
2.
Ciarleglio, G
: 1 article (11/2007)
3.
Collodoro, A
: 1 article (11/2007)
4.
De Santi, M M
: 1 article (11/2007)
5.
Federico, A
: 1 article (11/2007)
6.
Palmeri, S
: 1 article (11/2007)
Related Diseases
1.
Neoplasms (Cancer)
06/10/1983 - "
Ganglio-N-triaosylceramide (GalNAc beta 1 leads to 4Gal beta 1 leads to 4Glc beta 1 leads to 1Cer), a tumor-associated marker for L5178 cells, was previously reported to separate on thin layer chromatography into three distinct bands (bands a, b, and c).
"
01/01/1983 - "
Flow cytometric analysis revealed that asialo GM2 was undetectable on the surface of greater than 95% of the tumor cells from antibody-treated mice, whereas surface display of H-2 determinants was unchanged from that of the cells used for challenge.
"
01/01/1983 - "
These results suggest that serotherapy may complement a host anti-tumor response, from which only asialo GM2 deficient cells can escape.
"
02/01/1981 - "
Incorporation of asialo GM2 and gangliosides in cell surface of cultured metastatic and nonmetastatic BALB/3T3 cell lines: subcutaneous tumor cell take.
"
06/10/1983 - "
Characterization of tumor-associated ganglio-N-triaosylceramide in mouse lymphoma and the dependency of its exposure and antigenicity on the sialosyl residues of a second glycoconjugate.
"
2.
Lymphoma (Lymphomas)
06/10/1983 - "
Characterization of tumor-associated ganglio-N-triaosylceramide in mouse lymphoma and the dependency of its exposure and antigenicity on the sialosyl residues of a second glycoconjugate.
"
01/30/1981 - "
Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement.
"
01/01/1983 - "
Mice challenged with L5178Y lymphoma cells expression high levels of the glycolipid asialo GM2 (gangliotriosylceramide) were protected from tumor growth by passive administration of a monoclonal antibody specific for the glycolipid; in a few antibody-treated mice, ascites cells eventually proliferated which contained a reduced chemical quantity of the glycolipid antigen (3).
"
3.
Nervous System Diseases (Neurological Disorders)
05/01/1988 - "
The sera from 60 out of 102 cases of SLE with neurological disorders and 6 out of 10 patients with neuro Behçet's disease showed antibody activity against asialo GM1 but not against the asialo GM2, GM1 and galactocerebroside.
"
12/01/1980 - "
The sera from 14 out of 17 cases of SLE with neurological disorders showed antibody activity against asialo GM1 but not against the following glycolipids: asialo GM2 GM1, and galactocerebroside.
"
4.
Sandhoff Disease (Sandhoff's Disease)
11/01/2007 - "
Sandhoff disease, Gaucher disease type I and sialidosis type I are lysosomal storage disorders caused, respectively, by deficiency of activity of beta-hexosaminidase (storage of GM(2) and GA(2) ganglioside), glucosylceramidase (storage of glucosylceramide) and alpha-neuraminidase (storage of glucopeptides and/or oligosaccharides).
"
5.
Melioidosis
12/01/1997 - "
Burkholderia pseudomallei cells, the causative micro-organisms of melioidosis, were demonstrated to bind specifically to tissue glycolipids (asialo GM1 and asialo GM2) by solid phase binding assay on thin layer chromatograms.
"
Related Drugs and Biologics
1.
asialo GM1 ganglioside
2.
Glycolipids
3.
Glycosphingolipids
4.
Complement System Proteins (Complement)
5.
ganglio-N-triaosylceramide
6.
galactocerebroside
7.
Oligosaccharides
8.
Neuraminidase (Sialidase)
9.
Liposomes (Liposome)
10.
Immunoglobulins (Immunoglobulin)