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ganglio-N-triaosylceramide

Subscribe to New Research on ganglio-N-triaosylceramide

tumor associated marker for L5178 cells

Also Known As:

G(A(2)) Ganglioside; G(A2) ganglioside; GA(2) Ganglioside; GA2 ganglioside; GalNAc beta1-4Gal beta1-4Glc beta1-1Cer; acetylgalactosaminyl-1-4-galactosyl-1-4-glucosyl-1-1-ceramide; asialo GM2; gangliotriosylceramide; glycolipid G(A2); Ganglioside GA2

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Buccoliero, R: 1 article (11/2007)
2.	Federico, A: 1 article (11/2007)
3.	Palmeri, S: 1 article (11/2007)
4.	Ciarleglio, G: 1 article (11/2007)
5.	Collodoro, A: 1 article (11/2007)
6.	De Santi, M M: 1 article (11/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/10/1983 - "Ganglio-N-triaosylceramide (GalNAc beta 1 leads to 4Gal beta 1 leads to 4Glc beta 1 leads to 1Cer), a tumor-associated marker for L5178 cells, was previously reported to separate on thin layer chromatography into three distinct bands (bands a, b, and c). " 01/01/1983 - "Flow cytometric analysis revealed that asialo GM2 was undetectable on the surface of greater than 95% of the tumor cells from antibody-treated mice, whereas surface display of H-2 determinants was unchanged from that of the cells used for challenge. " 06/10/1983 - "Characterization of tumor-associated ganglio-N-triaosylceramide in mouse lymphoma and the dependency of its exposure and antigenicity on the sialosyl residues of a second glycoconjugate." 01/01/1983 - "These results suggest that serotherapy may complement a host anti-tumor response, from which only asialo GM2 deficient cells can escape." 02/01/1981 - "Incorporation of asialo GM2 and gangliosides in cell surface of cultured metastatic and nonmetastatic BALB/3T3 cell lines: subcutaneous tumor cell take."
2.	Lymphoma (Lymphomas) 06/10/1983 - "Characterization of tumor-associated ganglio-N-triaosylceramide in mouse lymphoma and the dependency of its exposure and antigenicity on the sialosyl residues of a second glycoconjugate." 01/30/1981 - "Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement. " 01/01/1983 - "Mice challenged with L5178Y lymphoma cells expression high levels of the glycolipid asialo GM2 (gangliotriosylceramide) were protected from tumor growth by passive administration of a monoclonal antibody specific for the glycolipid; in a few antibody-treated mice, ascites cells eventually proliferated which contained a reduced chemical quantity of the glycolipid antigen (3). "
3.	Nervous System Diseases (Neurological Disorders) 05/01/1988 - "The sera from 60 out of 102 cases of SLE with neurological disorders and 6 out of 10 patients with neuro Behçet's disease showed antibody activity against asialo GM1 but not against the asialo GM2, GM1 and galactocerebroside. " 12/01/1980 - "The sera from 14 out of 17 cases of SLE with neurological disorders showed antibody activity against asialo GM1 but not against the following glycolipids: asialo GM2 GM1, and galactocerebroside. "
4.	Sandhoff Disease (Sandhoff's Disease) 11/01/2007 - "Sandhoff disease, Gaucher disease type I and sialidosis type I are lysosomal storage disorders caused, respectively, by deficiency of activity of beta-hexosaminidase (storage of GM(2) and GA(2) ganglioside), glucosylceramidase (storage of glucosylceramide) and alpha-neuraminidase (storage of glucopeptides and/or oligosaccharides). "
5.	Mucolipidoses (Sialidosis) 11/01/2007 - "Sandhoff disease, Gaucher disease type I and sialidosis type I are lysosomal storage disorders caused, respectively, by deficiency of activity of beta-hexosaminidase (storage of GM(2) and GA(2) ganglioside), glucosylceramidase (storage of glucosylceramide) and alpha-neuraminidase (storage of glucopeptides and/or oligosaccharides). "

Related Drugs and Biologics

1.	asialo GM1 ganglioside
2.	Complement System Proteins (Complement)
3.	ganglio-N-triaosylceramide
4.	galactocerebroside
5.	Oligosaccharides
6.	Neuraminidase (Sialidase)
7.	Immunoglobulins (Immunoglobulin)
8.	Immunoglobulin M (IgM)
9.	Glycolipids
10.	Glucosylceramidase (Glucocerebrosidase)