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mitochondrial uncoupling protein (thermogenin)

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32,000 dalton uncoupling protein in mitochondrial cristae of brown adipocytes; amino acid sequence known; GenBank AJ223983 (Arabidopsis), Y11220 and AJ002586 ( Solanum tuberosum)

Also Known As:

thermogenin; uncoupling protein 1; BAT uncoupling protein; PUMP protein, Arabidopsis; UCP1 protein, human; Ucp1 protein, mouse; Ucp1 protein, rat; brown adipose tissue uncoupling protein; uncoupling mitochondrial protein, Arabidopsis; uncoupling protein 1 (mitochondrial, proton carrier), human; uncoupling protein 1, mitochondrial, mouse; uncoupling protein 1, rat; uncoupling protein 1a; uncoupling protein, mitochondrial membrane

Networked: 151 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Klingenspor, Martin: 3 articles (10/2014 - 01/2011)
2.	Flachs, P: 3 articles (08/2014 - 12/2004)
3.	Scarpace, P J: 3 articles (02/2013 - 01/2002)
4.	Scarpace, Philip J: 3 articles (04/2011 - 08/2002)
5.	Zhang, Yi: 3 articles (04/2011 - 08/2002)
6.	Saito, M: 3 articles (10/2008 - 11/2001)
7.	Kieffer, Timothy J: 2 articles (11/2015 - 12/2012)
8.	Fromme, Tobias: 2 articles (10/2014 - 01/2011)
9.	Bardova, K: 2 articles (08/2014 - 12/2004)
10.	Kopecký, J: 2 articles (08/2014 - 01/2013)

Related Diseases

1.	Obesity 05/01/2013 - "These brite (brown in white) adipocytes share characteristics with classical brown adipocytes including a multilocular appearance and the expression of the thermogenic protein uncoupling protein 1. In this study, we compared two inbred mouse strains 129S6sv/ev and C57BL6/N known for their different propensity to diet-induced obesity. " 12/01/1997 - "Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity." 05/01/1996 - "C57BL6/J mice with the expression of the mitochondrial uncoupling protein (UCP) gene from the fat-specific aP2 gene promoter were used to study the mechanism by which the aP2-Ucp transgene affects adiposity and reduces high-fat diet induced obesity. " 07/01/2015 - "Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 -3826A>G and ß3-adrenergic Receptor Trp64Arg Polymorphism." 05/01/2015 - "Brown and beige adipose tissue may represent important therapeutic targets for the treatment of diabetes and obesity as these organs dissipate nutrient energy as heat through the thermogenic uncoupling protein 1 (UCP1). "
2.	Body Weight (Weight, Body) 01/01/2015 - "Furthermore, this is accompanied by downregulation of uncoupling protein 1 expression and PPARγ coactivator-1 alpha in BAT and a rapid body weight gain. " 09/01/1983 - "When the thermogenin content of the animal was expressed per gram body weight, the content was more than doubled (from 22 to 47 pmol/g body weight) in the high EFA group, but was unaltered in the low EFA group. " 02/01/2007 - "Food intake, body weight, adiposity, and uncoupling protein 1 expression increased with antagonist infusion in controls but elevated only marginally in leptin-resistant rats. " 09/01/2005 - "Further, circulating levels of leptin were positively correlated with body weight and body fat mass, and negatively correlated with energy intake and uncoupling protein 1 contents. " 11/01/2003 - "However, MCH blockade led to a significant drop in body weight, which was accompanied by decreased liver glycogen, increased relative body fat, increased absolute and relative interscapular brown adipose tissue mass, increased uncoupling protein 1 expression in brown adipose tissue, and increased consumption of lean body mass. "
3.	Insulin Resistance 01/27/2006 - "Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes." 02/19/2008 - "Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1." 06/01/2002 - "To determine whether respiratory uncoupling can prevent insulin resistance-related hypertension, we crossed transgenic mice expressing uncoupling protein 1 (UCP1) in skeletal muscle with lethal yellow (A(y)/a) mice, genetically obese animals known to have elevated blood pressure. " 01/01/2005 - "Furthermore, brown adipocytes are also target cells for rosiglitazone action since they show a high expression of peroxisome proliferator activated receptor gamma, and rosiglitazone increased the expression of the thermogenic uncoupling protein 1. Rosiglitazone ameliorates insulin resistance provoked by TNF-alpha, completely restoring insulin-stimulated glucose uptake in parallel to the insulin signalling cascade. " 05/01/2004 - "This study analyzes the relationship between risk factors related to overweight/obesity, insulin resistance, lipid tolerance, hypertension, endothelial function and genetic polymorphisms associated with: i) appetite regulation (leptin, melanocortin-3-receptor (MCR-3), dopamine receptor 2 (D2R)); ii) adipocyte differentiation and insulin sensitivity (peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), tumor necrosis factor-alpha (TNF-alpha)); iii) thermogenesis and free fatty acid (FFA) transport/catabolism (uncoupling protein-1 (UCP1), lipoprotein lipase (LPL), beta2- and beta3-adrenergic receptor (beta2AR, beta3AR), fatty acid transport protein-1 (FATP-1) and iv) lipoproteins (apoliprotein E (apoE), apo CIII). "
4.	Atrophy 07/01/1985 - "Mitochondrial thermogenin content is unchanged during atrophy of BAT of fasting mice." 11/01/1986 - "The effects of unilateral surgical denervation on brown adipose tissue (BAT) composition were evaluated to assess the importance of the sympathetic innervation in the maintenance of a high concentration of the uncoupling protein thermogenin in cold-acclimated (CA) mice and to assess whether suppression of neural activity could account for BAT atrophy observed during fasting or when CA mice are returned to a thermoneutral environment (33 degrees C). " 07/01/1986 - "Fasting-induced atrophy was characterized by reductions in tissue mass, DNA, protein, and thermogenin. " 11/01/1986 - "Denervation-induced BAT atrophy was characterized by protein and thermogenin losses in absence of changes in the tissue cellularity (DNA content). " 08/01/1990 - "In euthyroid mice, a 48-h fast caused brown fat (BAT) atrophy characterized by loss of tissue proteins, succinate dehydrogenase (SDH), and a significant reduction in mitochondrial uncoupling protein (UCP) content. "
5.	Hypothermia 12/01/2008 - "Although physical activity is the dominant mechanism for dissipating excess energy, a system of thermogenesis that evolved to protect the body from hypothermia is based upon the uncoupling of oxidative phosphorylation in brown adipocytes by the mitochondrial uncoupling protein (UCP1). " 06/01/2013 - "Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in animals, conferring protection against diet-induced obesity and hypothermia through the action of uncoupling protein 1 (UCP1). " 10/01/2013 - "In contrast to white adipocytes, which store energy, brown adipocytes generate heat via mitochondrial uncoupling protein 1, thereby acting as a defence against hypothermia and, potentially, obesity. " 07/20/2012 - "Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Proteins (Proteins, Gene)
5.	PPAR gamma
6.	Succinate Dehydrogenase (Fumarate Reductase)
7.	rosiglitazone (Avandia)
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Lipoprotein Lipase (Diacylglycerol Lipase)
10.	mitochondrial uncoupling protein (thermogenin)

Related Therapies and Procedures

1.	Denervation
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Drug Therapy (Chemotherapy)