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Ro 22-4679

one-substituted imidazole thromboxane synthetase inhibitor; no other info available 6/21/83

Also Known As:

RO-22-4679

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Ro 22-4679: 4

Related Diseases

1.	Ventricular Fibrillation 04/01/1984 - "Comments on "The effects of RO-22-4679, a thromboxane synthetase inhibitor, on ventricular fibrillation induced by coronary artery occlusion in conscious dogs"." 05/01/1983 - "The effects of RO-22-4679, a thromboxane synthetase inhibitor, on ventricular fibrillation induced by coronary artery occlusion in conscious dogs." 02/01/1986 - "This effect of prostacyclin led to the evaluation of two structurally different inhibitors of thromboxane synthase in this preparation; RO 22-4679 and U-63557A reduced ventricular fibrillation by 82% and 100%, respectively (p less than .05). "
2.	Hypotension (Low Blood Pressure) 02/01/1985 - "They were randomly assigned to receive pretreatment with an infusion of saline (control, n = 8), a thromboxane synthetase inhibitor (RO-22-4679, n = 5), or a prostacyclin analogue that does not produce hypotension (ZK 36,374, n = 8). "

Related Drugs and Biologics

1.	Thromboxane-A Synthase
2.	Epoprostenol (Prostacyclin)
3.	Thromboxanes
4.	furegrelate